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Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
Zhao, Yanjun; Khengar, Raj; Traynor, M.J.; Barata, Pedro; Brown, Marc; Jones, Stuart (2012)The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ...