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Browsing by Author "Kinabo, L. D."
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Current models in pharmacokinetics : applications in veterinary pharmacology
Kinabo, L. D.; McKellar, Quintin (1989)Major advances in developing models for pharmacokinetic studies have been made in recent years, and different approaches can now be employed. These include the use of (1) compartmental models, (2) non-compartmental models, ... -
Determination of halofuginone in bovine plasma by competing-ion high performance liquid chromatography after solid phase extraction
Kinabo, L. D.; McKellar, Quintin; Murray, M. (1989)A high performance liquid chromatography (HPLC) method for the determination of the anticoccidial and antitheilerial drug halofuginone in bovine plasma was developed. Samples were diluted with acetic acid (10%, v/v) and ... -
Isometamidium in goats : disposition kinetics, mammary excretion and tissue residues
Kinabo, L. D.; McKellar, Quintin (1990-09)The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval ... -
Isometamidium in pigs : disposition kinetics, tissue residues and adverse reactions
Kinabo, L. D.; McKellar, Quintin; Eckersall, P. D. (1991-01)The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed ... -
Pharmacokinetics of ivermectin after oral or percutaneous administration to adult milking goats
Scott, E. W.; Kinabo, L. D.; McKellar, Quintin (1990-12) -
The pharmacology of flukicidal drugs
McKellar, Quintin; Kinabo, L. D. (1991-07) -
Relay bioavailability and toxicity of isometamidium residues : a model for human risk assessment
Kinabo, L. D.; Bogan, J. A.; McKellar, Quintin; Murray, M. (1989)The bioavailability and potential toxicity of the residues of the antitrypanosomal drug isometamidium (ISMM) in bovine tissues were investigated in male Sprague-Dawley rats. They were allowed to feed for 7 and 21 days on ...