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Browsing by Author "Kirkby, Nick"
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Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation : implications for a clinical test
Kirkby, Nick; Chan, M.V.; Lundberg, M.H.; MacKenzie, Louise; Leadbeater, Phillip D.M.; Milne, Ginger L.; Potter, Claire M.; Al-Yamani, Malak; Adeyemi, Oladipupo; Warner, Tim D.; Mitchell, Jane A. (2013-10)Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin ... -
Role of COX-1 and COX-2 in the release of prostanoids in murine lung and isolated lung fibroblasts
Wright, William; Kirkby, Nick; MacKenzie, Louise Susan; Lundberg, Martina; Paul-Clark, M.J.; Warner, T.D. (2011-06)Cyclooxygenase (COX) is the first enzyme in the conversion of arachidonic acid to prostanoids. There are two isoforms of COX; COX-1, which is constitutively expressed with a homeostatic role in most tissues, and COX-2, ... -
Role of prostacyclin in pulmonary hypertension
Mitchell, Jane A.; Ahmetaj-Shala, Blerina; Kirkby, Nick; Wright, William R.; MacKenzie, Louise Susan; Reed, Dan; Mohamed, Nura (2014-12-31)Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads ...