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Browsing by Author "Klapwijk, Jan"
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Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis.
Bodhaniya, Aateka; Hoffman, Ewelina; Ball, Dough; Klapwijk, Jan; Steven, Rory T.; Dexter, Alex; Bunch, Josephine; Baker, Daniel; Murnane, Darragh; Hutter, Victoria; Page, Clive; Dailey, Lea Ann; Forbes, Ben (2019-07-17)‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally ... -
Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis
Dexter, Alex; Steven, Rory T; Patel, Aateka; Dailey, Lea Ann; Taylor, Adam J; Ball, Doug; Klapwijk, Jan; Forbes, Ben; Page, Clive P; Bunch, Josephine (2019-12)Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry ... -
Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
Hoffman, Ewelina; Bodhaniya, Aateka; Ball, Doug; Klapwijk, Jan; Millar, Val; Kumar, Abhinav; Martin, Abigail; Mahendran, Rhamiya; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2017-12-31)Purpose. Progress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study ...