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3D Printing: Advancements in the Development of Personalised Pharmaceuticals for Older Adults
Awad, Atheer; Januskaite, Patricija; Alkahtani, Manal; Orlu, Mine; Basit, Abdul W. (Springer Nature, 2023-11-11)Three-dimensional (3D) printing is a revolutionary additive manufacturing technology that constructs objects layer-by-layer. This versatile technology encompasses various processes and possesses unique properties. While ... -
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size
Vallet, Thibault; Michelon , Hugues; Orlu, Mine; Jani, Yogini Hariprasad; Leglise , Patrick; Laribe-Caget , Sandra; Piccoli, Matthieu; Le Fur , Aurélie; Liu, Fang; Ruiz , Fabrice; Boudy , Vincent (2020-08-08)Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia ... -
Acceptability of oral solid medicines in older adults with and without dysphagia : a nested pilot validation questionnaire based observational study
Liu, Fang; Ghaffur, Ambreen; Bains, Jackreet; Hamdy, Shaheen (2016-10-30)Older patients (aged 65 years and over) are the major consumers of medicines and many barriers affect their ability in taking medicines orally, especially swallowing difficulties. Moreover, the characteristics of differing ... -
Advances in oral transmucosal drug delivery
Patel, Viralkumar F.; Liu, Fang; Brown, Marc (2011-07-30)The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond ... -
Age-mediated changes in the gastrointestinal tract
Merchant, Hamid; Liu, Fang; Orlu Gul, Mine; Basit, Abdul (2016-10-30)Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of ... -
Apparatus, buffer and method for pH control
School of Life and Medical Sciences; Department of Clinical and Pharmaceutical Sciences; Centre for Research into Topical Drug Delivery and Toxicology; Pharmaceutics; Pharmaceutical Analysis and Product Characterisation; Bioadhesive Drug Delivery Group; Liu, Fang; Curl, Andrew; Fitzgerald , Dean (2019-04) -
Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development
Merchant, Hamid A.; McConnell, Emma L.; Liu, Fang; Ramaswamy, Chandrasekaran; Kulkarni, Rucha P.; Basit, Abdul W.; Murdan, Sudaxshina (2011-01-18)Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem ... -
Assessment of swallowability and palatability of oral dosage forms in children : Report from an M-CERSI pediatric formulation workshop
Ternik, Robert; Liu, Fang; Bartlett, Jeremy A; Khong, Yuet Mei; Thiam Tan, David Cheng; Dixit, Trupti; Wang, Siri; Galella, Elizabeth A; Gao, Zhihui; Klein, Sandra (2018-02-05)The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic outcome. However, existing methodology and approaches used for acceptability ... -
Can children swallow tablets? Outcome data from a feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people (Creating Acceptable Tablets - CAT)
Bracken, Louise; McDonough, Emma; Ashleigh, Samantha; Wilson, Fiona; Shakeshaft, Joanne; Ohia, Udeme; Mistry, Punam; Jones, Huw; Kanji, Nazim; Liu, Fang; Peak, Matthew (2020-10-10)Objective Feasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years. Design and setting Clinical Research Facilities, inpatient wards and outpatient clinics within a ... -
Colonic treatments and targets : issues and opportunities
McConnell, E. L.; Liu, Fang; Basit, A.W. (2009)The colon provides a plethora of therapeutic opportunities. There are multiple disease targets, drug molecules, and colon-specific delivery systems to be explored. Clinical studies highlight the potential for systemic ... -
Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
Patel, Simmi; Scott, Nathan; Patel, Kavil; Mohylyuk, Valentyn; McAuley, William; Liu, Fang (2020-04-29)It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient ... -
European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.
Salunke , Smita; Liu, Fang; Batchelor, Hannah; Walsh, Jenny; Turner, Roy; Ju, Tzuchi; Tuleu, Catherine (2017-02-01)The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It ... -
European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.
Salunke , Smita; Liu, Fang; Batchelor, Hannah; Walsh, Jenny; Turner, Roy; Ju, Tzuchi; Tuleu, Catherine (2017-02-01)The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It ... -
European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.
Salunke , Smita; Liu, Fang; Batchelor, Hannah; Walsh, Jenny; Turner, Roy; Ju, Tzuchi; Tuleu, Catherine (2017-02-01)The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It ... -
Foreword: Special issue—geriatric drug therapy
Orlu Gul, Mine; Liu, Fang; Hughes, Camel (2016-10-30) -
Formulation factors affecting acceptability of oral medicines in children
Liu, Fang; Ranmal, Sejal; Batchelor, Hannah K.; Orlu-Gul, Mine; Ernest, Terry B.; Thomas, Iwan W.; Flanagan, Talia; Kendall, Richard; Tuleu, Catherine (2015-08-15)Acceptability of medicines in children and caregivers affects safety and effectiveness of medicinal treatments. The pharmaceutical industry is required to demonstrate acceptability of new paediatric formulations in target ... -
How useful are medication patient information leaflets to older adults? : A content, readability and layout analysis
Liu, Fang; Abdul-Hussain, Sarah; Mahboob, Shams; Rai, Vijay; Kostrzewski, Andrzej (2014-08)BACKGROUND: Patient information leaflets (PILs) are the most important information source for older patients to effectively manage their drug therapy.OBJECTIVE: The objective of this study is to evaluate the appropriateness ... -
In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer
Liu, Fang; Shokrollahi, Honaz (2015-05-15) -
An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans
Ibekwe, Valentine C.; Liu, Fang; Fadda, Hala M.; Khela, Mandeep K.; Evans, David F.; Parsons, Gary E.; Basit, Abdul W. (2006-12)Gastrointestinal performance of tablets coated with pH responsive acrylic polymers (Eudragit) was investigated in human volunteers. Tablet cores were coated with Eudragit S dissolved in ethanol (organic), Eudragit S aqueous ... -
Meeting commentary-"Parkinson's disease : From patient to product"
Wahlich, John; Elder, David; Liu, Fang; Hughes, Carmel; Orlu-Gul, Mine (2015-10-15)A meeting organised by the Academy of Pharmaceutical Sciences (APSGB) Age-Related Medicines Focus Group took place on the 19th of May 2015, in GlaxoSmithKline Ware, UK [∗]. The meeting was the first of a planned series of ...