- UHRA Home
- Browsing by Author
Browsing by Author "McAuley, William"
Now showing items 1-14 of 14
-
Determination of the diffusion coefficient of cyanophenol in carbosil membrane using ATR-FTIR spectroscopy
McAuley, L.; Santos, P.; Lane, M. E.; Hadgraft, J.; McAuley, William (2006-09)Model membranes are often used in place of human skin when evaluating dermal drug delivery systems. This is because they offer several advantages compared with human epidermis including their ready availability, uniformity ... -
Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
Patel, Simmi; Scott, Nathan; Patel, Kavil; Mohylyuk, Valentyn; McAuley, William; Liu, Fang (2020-04-29)It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient ... -
The effect of dilution of fusidic acid cream and betamethasone dipropionate cream in complex extemporaneous mixes on formulation performance
Beebeejaun, Mubinah; Brown, Marc; Hutter, Victoria; Kravitz, Laura; McAuley, William (2022-08-25)The Aron regimen is an unconventional therapy which entails frequent applications of an extemporaneously prepared three component system (a topical antibiotic, a corticosteroid and an emollient), with the intention of ... -
Effect of Transdermal Magnesium Cream on Serum and Urinary Magnesium Levels in Humans: A Pilot Study
Kass, Lindsy; Rosanoff, Andrea; Tanner, Amy; McAuley, William; Sullivan, Keith; Plesset, Michael (2017-04-12)Background Oral magnesium supplementation is commonly used to support a low magnesium diet. This investigation set out to determine whether magnesium in a cream could be absorbed transdermally in humans to improve magnesium ... -
Enhanced follicular delivery of finasteride to human scalp skin using heat and chemical penetration enhancers
Farah, Hassan; McAuley, William; Brown, Marc (2020-05-31)Purpose The aim of this work was to evaluate whether improved topical delivery of finasteride, focussed to the hair follicles of human scalp skin could be achieved with application of short durations of heat and use of ... -
Heat enhanced follicular delivery of isotretinoin to the skin
Farah, Hassan; Brown, Marc; McAuley, William (2019-08-01)Purpose: The aim of this work was to evaluate the use of short durations of externally applied heat with chemical penetration enhancers to improve delivery of isotretinoin to the skin and in particular via the follicular ... -
Hydrophobicity and Partitioning
McAuley, William (Oxford University Press (OUP), 2013) -
The permeability of human eyelid skin to topically applied lidocaine
Emeriewen, K.; McAuley, William; Beebeejaun, Mubinah; Cook, Michael T.; Saleh, G.M. (2020-02-01)This work investigated the permeability of lidocaine across human eyelid skin and compared this with published data for abdominal skin to understand the characteristics of this type of skin and whether topical anaesthesia ... -
Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration
Haddow, Peter; McAuley, William; Kirton, Stewart; Cook, Michael T. (2020-05-06)Poly(N-isopropyl acrylamide) – block– poly(ethylene glycol) – block– poly(N-isopropyl acrylamide) is known to exhibit a thermally-induced solution-to-gel transition in water, which may be exploited for biomedical applications. ... -
Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare
Cook, Michael T.; Haddow, Peter; Kirton, Stewart; McAuley, William (2020-11-20)The ability to trigger changes to material properties with external stimuli, so-called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature ... -
Rationalising polymer selection for supersaturated film forming systems produced by an aerosol spray for the transdermal delivery of methylphenidate
Edwards, Andrew; Qi, Sheng; Liu, Fang; Brown, Marc; McAuley, William (2017-05-01)Film forming systems offer a number of advantages for topical and transdermal drug delivery, in particular enabling production of a supersaturated state which can greatly improve drug absorption and bioavailability. However ... -
The Swallowing Characteristics of Thickeners, Jellies and Yoghurt Observed Using an In Vitro Model
Patel, Simmi; McAuley, William; Cook, Michael T.; Sun, Yi; Hamdy, Shaheen; Liu, Fang (2019-11-09)Drinks and foods may be thickened to improve swallowing safety for dysphagia patients, but the resultant consistencies are not always palatable. Characterising alternative appetising foods is an important task. The study ... -
The use of optical differential scanning calorimetry to investigate ibuprofen miscibility in polymeric films for topical drug delivery
Livecchi, Luca; McAuley, William; Kerai-Varsani, Laxmi (2021-10-14)Understanding drug miscibility in pharmaceutically relevant systems is essential for the development and optimisation of pharmaceutical dosage forms. This is particularly true for film forming systems which are designed ... -
The use of polymer blends to improve stability and performance of electrospun solid dispersions: The role of miscibility and phase separation
Tipduangta, Pratchaya; Belton, Peter; McAuley, William; Qi, Sheng (2021-06-01)Solid dispersion-based nanofiber formulations of poorly soluble drugs prepared by electrospinning (ES) with a water-soluble polymer, can offer significant improvements in drug dissolution for oral drug administration. ...