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Browsing by Author "McAuley, William J."
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Physical stabilization of low-molecular-weight amorphous drugs in the solid state : a material science approach
Qi, Sheng; McAuley, William J.; Yang, Ziyi; Tipduangta, Pratchaya (2014-07)Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much ... -
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material
Haddow, Peter J.; da Silva, Marcelo A.; Kaldybekov, Daulet B.; Dreiss, Cecile A.; Hoffman, Ewelina; Hutter, Victoria; Khutoryanskiy, Vitaliy V.; Kirton, Stewart B.; Mahmoudi, Najet; McAuley, William J.; Cook, Michael T. (2021-12-11)Thermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which ... -
Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy
McAuley, William J.; Mader, Kerstin T.; Tetteh, John; Lane, Majella E.; Hadgraft, Jonathan (2009-11-05)Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to simultaneously follow the diffusion of model drugs and solvent across polydimethylsiloxane (silicone) membrane. Three model ... -
Skin permeation and penetration of mometasone furoate in the presence of emollients: An ex vivo evaluation of clinical application protocols
Beebeejaun, Mubinah T.; Brown, Marc B.; Hutter, Victoria; Kravitz, Laura; McAuley, William J. (2023-01-20)Background: Topical corticosteroids (TCS) and emollients are developed independently by the pharmaceutical industry but are often used together in practice. There is potential for the TCS and emollient formulations to ... -
Thermoresponsive Triblock‐Copolymers of Polyethylene Oxide and Polymethacrylates: Linking Chemistry, Nanoscale Morphology, and Rheological Properties
da Silva, Marcelo Alves; Haddow, Peter; Kirton, Stewart B.; McAuley, William J.; Porcar, Lionel; Dreiss, Cécile A.; Cook, Michael T. (2022-02-23)Abstract: Thermoreversible gels switch from a free‐flowing liquid state to an elastic gel mesophase upon warming, displaying the reverse transition upon cooling. While this phenomenon makes these advanced materials highly ...