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Browsing by Author "McAuley, William James"
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The effects of esterified solvents on the diffusion of a model compound across human skin : An ATR-FTIR spectroscopic study
McAuley, William James; Chavda-Sitaram, Sonal; Mader, Kerstin; Tetteh, John; Lane, Majella; Hadgraft, Jonathan (2013-04)Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to investigate the effects of three fatty acid esters on skin permeation. Propylene glycol diperlargonate (DPPG), isopropyl ... -
Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery : kinetic modelling and practical implications
Qi, Sheng; Belton, Peter; McAuley, William James; Codoni, Dorothy; Darji, Neerav (2013-04)Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, ... -
Pharmacokinetics of topical products
McAuley, William James; Kravitz, Laura (2012-06)Pharmacokinetics is the study of changes in drug concentrations in the body with time. It is commonly considered in four main phases: absorption, distribution, metabolism and excretion. Following topical administration, ... -
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films
Ng, Yuen Chuen; Yang, Ziyi; McAuley, William James; Qi, Sheng (2013-08)In this study, the stabilization effects of three polymers on four model drugs (felodipine, fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated. Three different types of thin films (solid ...