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Browsing by Author "Mohylyuk, Valentyn"
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Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology
Mohylyuk, Valentyn; Styliari, Ioanna Danai; Novykov, Dmytryi; Pikett, Reiss; Dattani, Rajeev (2019-12)The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder ... -
Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
Patel, Simmi; Scott, Nathan; Patel, Kavil; Mohylyuk, Valentyn; McAuley, William; Liu, Fang (2020-04-29)It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient ... -
Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing of enteric coated tablets, pellets and microparticles
Scott, Nathan; Patel, Kavil; Sithole, Tariro; Xenofontos, Konstantina; Mohylyuk, Valentyn; Liu, Fang (2020-07-30)Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a ... -
Wurster fluidised bed coating of microparticles: Towards scalable production of oral sustained-release liquid medicines for patients with swallowing difficulties
Mohylyuk, Valentyn; Patel, Kavil; Scott, Nathan; Craig Richardson; Murnane, Darragh; Liu, Fang (2019-11-11)Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release ...