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Browsing by Author "Moss, Gary P."
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The application of Gaussian processes in the prediction of percutaneous absorption
Moss, Gary P.; Sun, Yi; Prapopoulou, Maria; Davey, N.; Adams, Roderick; Pugh, W. John; Brown, Marc (2009-09)Objectives The aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a predictive model for skin permeability, comparing it with existing ... -
An evaluation of the potential of linear and nonlinear skin permeation models for the prediction of experimentally measured percutaneous drug absorption
Brown, Marc; Lau, Chi-Hian; Lim, Sian T.; Sun, Yi; Davey, N.; Moss, Gary P.; Yoo, Seon-Hie; De Muynck, Christian (2012-04)Objectives: The developments in combinatorial chemistry have led to a rapid increase in drug design and discovery and, ultimately, the production of many potential molecules that require evaluation. Hence, there has been ... -
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
Reid, Monica L.; Brown, Marc; Moss, Gary P.; Jones, Stuart A. (2008-09)The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ... -
Mathematical modelling of percutaneous absorption
Moss, Gary P.; Wilkinson, Simon C.; Sun, Yi (2012-06)This review examines recent progress made in the field of modelling and predicting percutaneous absorption. It describes initial qualitative modelling and how quantitative approaches were pioneered and then developed. ...