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Browsing by Author "Nikolic, Margareta"
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Cortical interneurons require p35/Cdk5 for their migration and laminar organization
Rakić, Sonja; Yanagawa, Yuchio; Obata, Kunihiko; Faux, Clare; Parnavelas, John G; Nikolic, Margareta (2009)Projection neurons and interneurons populate the cerebral cortex in a layer-specific manner. Here, we studied the role of Cyclin-dependent kinase 5 (Cdk5) and its activator p35 in cortical interneuron migration and disposition ... -
Neurabin-I is phosphorylated by Cdk5 : Implications for neuronal morphogenesis and cortical migration
Causeret, F.; Jacobs, T.; Terao, M.; Heath, O.; Hoshino, M.; Nikolic, Margareta (2007-11-01)The correct morphology and migration of neurons, which is essential for the normal development of the nervous system, is enabled by the regulation of their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific ... -
Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex
Hoerder-Suabedissen, A.; Wang, W.Z.; Lee, S.; Paulsen, O.; Molnár, Z.; Davies, K.E.; Goffinet, A.M.; Rakić, S.; Parnavelas, J.; Reim, K.; Nicolić, M.; Nikolic, Margareta (2009-08-01)The subplate lays the foundation of the developing cerebral cortex, and abnormalities have been suggested to contribute to various brain developmental disorders. The causal relationship between cellular pathologies and ... -
The p21-activated kinase is required for neuronal migration in the cerebral cortex
Causeret, F.; Terao, M.; Jacobs, T.; Nishimura, Y.V.; Yanagawa, Y.; Obata, K.; Hoshino, M.; Nikolic, Margareta (2009-04-01)The normal formation and function of the mammalian cerebral cortex depend on the positioning of its neurones, which occurs in a highly organized, layer-specific manner. The correct morphology and movement of neurones rely ... -
The Pak1 kinase : an important regulator of neuronal morphology and function in the developing forebrain
Nikolic, Margareta (2008-06)The mammalian central nervous system (CNS) represents a highly complex unit, the correct function of which relies on the appropriate differentiation and survival of its neurones. It is becoming apparent that the Rho family ... -
Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex
Rakić, Sonja; Davis, Colin; Molnár, Zoltán; Nikolic, Margareta; Parnavelas, John G. (2006)The earliest generated cells of the mammalian cerebral cortex form the preplate layer (PPL). The subsequently born cortical plate (CP) cells split this layer into the superficial layer I (LI) and the deep subplate (SP). ...