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Browsing by Author "O'Connor, Rachael"
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Comparison of oritavancin versus vancomycin as treatments for clindamycin-induced Clostridium difficile PCR ribotype 027 infection in a human gut model
Baines, Simon D.; O'Connor, Rachael; Saxton, Katie; Freeman, Jane; Wilcox, Mark H. (2008)To compare the efficacy of oritavancin and vancomycin in the treatment of Clostridium difficile infection (CDI) using an in vitro human gut model. -
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model
Saxton, Katie; Baines, Simon D.; Freeman, Jane; O'Connor, Rachael; Wilcox, M. H. (2009)The incidence of Clostridium difficile infection is increasing, with reports implicating fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of three fluoroquinolones (ciprofloxacin, ... -
Emergence of reduced susceptibility to metronidazole in Clostridium difficile
Baines, Simon D.; O'Connor, Rachael; Freeman, Jane; Fawley, Warren N; Harmanus, Celine; Mastrantonio, Paola; Kuijper, Ed J.; Wilcox, M. H. (2008)Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for ... -
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
Baines, Simon D.; Noel, Alan R.; Huscroft, Grace S.; Todhunter, Sharie L.; O'Connor, Rachael; Hobbs, Joanne K.; Freeman, Jane; Lovering, Andy M.; Wilcox, M. H. (2011)Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI. -
In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin
O'Connor, Rachael; Baines, Simon D.; Freeman, Jane; Wilcox, Mark H. (2008)Clostridium difficile infection is a nosocomial disease of increasing importance. First-line treatment is limited to metronidazole or vancomycin. Oritavancin is a lipoglycopeptide with activity against Gram-positive bacteria, ... -
Mecillinam : a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; O'Connor, Rachael; Huscroft, Grace; Saxton, Katie; Freeman, Jane; Wilcox, Mark H (2009)