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Browsing by Author "Patel, Hershna"
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Antiviral Drug Target Identification and Ligand Discovery
Patel, Hershna; Sengupta, Dipankar (Humana Press, 2023-09-08)This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then ... -
Evaluation of a novel virtual screening strategy using receptor decoy binding sites
Patel, Hershna; Kukol, Andreas (2016-08-23)Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet ... -
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors
Patel, Hershna; Kukol, Andreas (2017-09-01)The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions ... -
Evolutionary Targeted Discovery of Influenza A Virus Replication Inhibitors
Patel, Hershna (2018-01-29)Influenza A is one of the most prevalent and significant viral infections worldwide, resulting in annual epidemics and occasional pandemics. Upon infection, antiviral drugs targeting the neuraminidase protein and M2 protein ... -
Influenza A nucleoprotein binding sites for antivirals: : current research and future potential
Kukol, A.; Patel, Hershna (2014-09-15) -
Integrating molecular modelling methods to advance influenza A virus drug discovery
Patel, Hershna; Kukol, Andreas (2020-11-19)Since the discovery of the anti-influenza drugs Oseltamivir and Zanamivir using computer aided drug design methods, there have been significant applications of molecular modelling methodologies applied to influenza A virus ... -
Molecular modeling of influenza A virus proteins
Patel, Hershna; Rapley, Ralph; Kukol, Andreas (2015-12-08) -
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
Ahmad, Mohammed Saqif; Braoudaki, Maria; Patel, Hershna; Ahmad, Irshad; Waseem, Shagufta; Siddiqui, Shoib (2023-10-06)Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ... -
Prediction of ligands to universally conserved binding sites of the influenza A virus nuclear export protein
Patel, Hershna; Kukol, Andreas (2019-11-01)The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular ... -
Recent discoveries of influenza A drug target sites to combat virus replication
Patel, Hershna; Kukol, Andreas (2016-06-09)Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential ...