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        Recent discoveries of influenza A drug target sites to combat virus replication

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        Accepted_Manuscript.pdf (PDF, 881Kb)
        Author
        Patel, Hershna
        Kukol, Andreas
        Attention
        2299/17457
        Abstract
        Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.
        Publication date
        2016-06-09
        Published in
        Biochemical Society Transactions
        Published version
        https://doi.org/10.1042/BST20160002
        Other links
        http://hdl.handle.net/2299/17457
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