dc.contributor.author | Patel, Hershna | |
dc.contributor.author | Kukol, Andreas | |
dc.date.accessioned | 2016-12-21T16:35:48Z | |
dc.date.available | 2016-12-21T16:35:48Z | |
dc.date.issued | 2016-06-09 | |
dc.identifier.citation | Patel , H & Kukol , A 2016 , ' Recent discoveries of influenza A drug target sites to combat virus replication ' , Biochemical Society Transactions , vol. 44 , no. 3 , pp. 932-36 . https://doi.org/10.1042/BST20160002 | |
dc.identifier.issn | 0300-5127 | |
dc.identifier.uri | http://hdl.handle.net/2299/17457 | |
dc.description | This is the accepted version of the following article: H. Patel and A. Kukol, ‘Recent discoveries of influenza A drug target sites to combat virus replication’, Biochemical Society Transactions, 44(3): 932-936, Portland Press, which has been published in final form at doi: 10.1042/BST20160002 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society | |
dc.description.abstract | Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies. | en |
dc.format.extent | 5 | |
dc.format.extent | 902664 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biochemical Society Transactions | |
dc.subject | influenza A | |
dc.subject | viral proteins | |
dc.subject | antiviral discovery | |
dc.subject | resistance | |
dc.subject | inhibitors | |
dc.title | Recent discoveries of influenza A drug target sites to combat virus replication | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Future Societies Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1042/BST20160002 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |