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Browsing by Author "Patterson, Laurence H."
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Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells
Errington, Rachel J.; Ameer-Beg, S. M.; Vojnovic, B.; Patterson, Laurence H.; Zloh, Mire; Smith, P. J. (2005)Many anticancer drugs require interaction with DNA or chromatin components of tumor cells to achieve therapeutic activity. Quantification and exploration of drug targeting dynamics can be highly informative in the rational ... -
Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells
Njoh, Kerenza L.; Patterson, Laurence H.; Zloh, Mire; Wiltshire, Marie; Fisher, Janet; Chappell, Sally; Ameer-Beg, Simon; Bai, Yanhong; Matthews, Daniel; Errington, Rachel J.; Smith, Paul J. (2006-08)We report on the potential DNA binding modes and spectral characteristics of the cell-permeant far red fluorescent DNA dye, DRAQ5, in solution and bound within intact cells. Our aim was to determine the constraints for its ... -
Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones : potential for development of tumor-selective N-oxides
Pors, Klaus; Shnyder, Steven D.; Teesdale-Spittle, Paul H.; Hartley, John A.; Zloh, Mire; Searcey, Mark; Patterson, Laurence H. (2006)A novel series of 1,4-disubstituted chloroethylaminoanthraquinones, containing alkylating chloroethylamino functionalities as part of a rigid piperidinyl or pyrrolidinyl ring-system, have been prepared. The target compounds ...