- UHRA Home
- Browsing by Author
Browsing by Author "Pritchard, David"
Now showing items 1-3 of 3
-
Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture model
Hutter, Victoria; Hilgendorf, Constanze; Brown, Alan; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2010-10)Expression and functionality of ATP-binding cassette (ABC) transporters were assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Transporter gene expression was in agreement with published data in human ... -
Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.
Hutter, Victoria; Hilgendorf, Constanze; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2012-09-29)A rat respiratory epithelial cell culture system for in vitro prediction of drug pulmonary absorption is currently lacking. Such a model may however enhance the understanding of interspecies differences in inhaled drug ... -
Expression and functionality of P-glycoprotein in human bronchial epithelial cells in vitro
Hutter, Victoria; Hilgendorf, Constanze; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2011-09)P-glycoprotein (P-gp) is expressed in normal tissues with barrier functions where it participates in cell defence mechanisms (Huls, M. et al. J Pharm Exp Ther 2009; 328:3-9). Its presence in the bronchial epithelium and ...