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Browsing by Author "Pritchard, Sara"
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Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate
Coletto, Erika; Tough, Ian; Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Jenner, Peter; Chaudhuri, K. Ray; Cox, Helen; Iravani, Mahmoud; Rose, Sarah (2021-01-21)The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical ... -
Modulation of TRPV1 Function in Sensory Neuropathy
Pritchard, Sara (University of Hertfordshire, 2015-02-03)This thesis examined how and why TRPV1 function is being modulated in sensory neuropathy and explored the potential of its rescue in the urinary bladder of STZ-‐induced diabetic rats. Diabetes ... -
The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)
Pritchard, Sara; Jackson, Michael; Lione, Lisa; Benham, Christopher; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M. (2013-12)Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common ...