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        The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)

        Author
        Pritchard, Sara
        Jackson, Michael
        Lione, Lisa
        Benham, Christopher
        Rose, Sarah
        Jenner, Peter
        Iravani, Mahmoud M.
        Attention
        2299/14433
        Abstract
        Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)
        Publication date
        2013-12
        Published in
        pA2 online
        Other links
        http://hdl.handle.net/2299/14433
        Relations
        School of Life and Medical Sciences
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