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dc.contributor.authorPritchard, Sara
dc.contributor.authorJackson, Michael
dc.contributor.authorLione, Lisa
dc.contributor.authorBenham, Christopher
dc.contributor.authorRose, Sarah
dc.contributor.authorJenner, Peter
dc.contributor.authorIravani, Mahmoud M.
dc.date.accessioned2014-09-08T13:45:46Z
dc.date.available2014-09-08T13:45:46Z
dc.date.issued2013-12
dc.identifier.citationPritchard , S , Jackson , M , Lione , L , Benham , C , Rose , S , Jenner , P & Iravani , M M 2013 , ' The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus) ' , pA2 online , vol. 11 , no. 3 , 208P .
dc.identifier.otherPURE: 7545908
dc.identifier.otherPURE UUID: 1fea178e-2daf-4c21-9582-4b551d0ccbc1
dc.identifier.urihttp://hdl.handle.net/2299/14433
dc.description.abstractDysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)en
dc.language.isoeng
dc.relation.ispartofpA2 online
dc.titleThe spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.pA2online.org/abstracts/Vol11Issue3abst208P.pdf
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2013-12
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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