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Browsing by Author "Prowse, David M."
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Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas
Stankiewicz, Elzbieta; Prowse, David M.; Ng, Mansum; Cuzick, Jack; Mesher, David; Hiscock, Frances; Lu, Yong Jie; Watkin, Nicholas; Corbishley, Catherine; Lam, Wayne; Berney, Daniel M. (2011-03-10)Background: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood, though risk factors include human papillomavirus (HPV). Disruption of HER/PTEN/Akt pathway is present in many cancers; however ... -
Association between mouse nude gene expression and the initiation of epithelial terminal differentiation
Lee, David; Prowse, David M.; Brissette, Janice L. (1999-04-15)Loss-of-function mutations in Whn (Hfh 11), a winged-helix/forkhead transcription factor, result in the nude mouse phenotype. To determine the whn expression pattern during development, we utilized mice in which a β- ... -
Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells
Mao, Xueying; Shaw, Greg; James, Sharon Y.; Purkis, Patricia; Kudahetti, Sakunthala C.; Tsigani, Theodora; Kia, Saname; Young, Bryan D.; Oliver, R. Tim D; Berney, Dan; Prowse, David M.; Lu, Yong Jie (2008-05-01)Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis. Methods: We analyzed the frequency of TMPRSS2: ... -
Developmental signals in skin morphogenesis
Prowse, David M. (2004-10-01) -
Distinct epidermal stem cell compartments are maintained by independent niche microenvironments
Braun, Kristin M.; Prowse, David M. (2006-09-01)The mammalian epidermis is a stratified, multilayered epithelium, consisting of the interfollicular epidermis and associated appendages, which extend into the dermis and include hair follicles, sebaceous glands, and sweat ... -
E-cadherin expression can alter the specificity of gap junction formation
Prowse, David M.; Cadwallader, G. P.; Pitts, J. D. (1997-12-01)Specificity of gap junction formation produces communication compartments, groups of cells joined to each other by gap junctions (homologous communication) but more rarely to cells in adjacent compartments (heterologous ... -
Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation : Implications for the self-renewal of cutaneous epithelia
Prowse, David M.; Lee, David; Weiner, Lorin; Jiang, Nanyan; Magro, Cynthia M.; Baden, Howard P.; Brissette, Janice L. (1999-08-01)Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. ... -
Editorial comment
Prowse, David M. (2008-07-01) -
Exposing the human nude phenotype [4]
Frank, J.; Pignata, C.; Panteleyev, A. A.; Prowse, David M.; Baden, H.; Weiner, L.; Gaetaniello, L.; Ahmad, W.; Pozzi, N.; Cserhalmi-Friedman, P. B.; Aita, V. M.; Uyttendaele, H.; Gordon, D.; Ott, J.; Brissette, J. L.; Christiano, A. M. (1999-04-08) -
Gli1 confers profound phenotypic changes upon lncap prostate cancer cells that include the acquisition of a hormone independent state
Nadendla, Sandeep K.; Hazan, Allon; Ward, Matt; Harper, Lisa J.; Moutasim, Karwan; Bianchi, Lucia S.; Naase, Mahmoud; Ghali, Lucy; Thomas, Gareth J.; Prowse, David M.; Philpott, Michael P.; Neill, Graham W. (2011-05-30)The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is ... -
Hedgehog Signalling in Androgen Independent Prostate Cancer
Shaw, Greg; Price, Anna M.; Ktori, Elena; Bisson, Isabelle; Purkis, Patricia E.; McFaul, Siobhan; Oliver, R. Tim D; Prowse, David M. (2008-12-01)Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis. However prolonged androgen deprivation generally results in relapse and ... -
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
Stankiewicz, Elzbieta; Kudahetti, Sakunthala C.; Prowse, David M.; Ktori, Elena; Cuzick, Jack; Ambroisine, Laurence; Zhang, Xiaoxi; Watkin, Nicholas; Corbishley, Catherine; Berney, Daniel M. (2009-09-01)Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series ... -
Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients
Husain, Ehab; Prowse, David M.; Ktori, Elena; Shaikh, Taufiq; Yaqoob, Magdi; Junaid, Islam; Baithun, Suhail (2009-11-09)Aims: We investigated the role of human papillomavirus HPV in the development of transitional cell carcinoma TCC arising in renal transplant recipients. Methods: Genomic DNA was extracted from 10 m paraffin embedded sections ... -
Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma
Prowse, David M.; Ktori, E. N.; Chandrasekaran, D.; Prapa, A.; Baithun, S. (2008-02-01)Background: Human papillomaviruses (HPVs) are sexually transmitted human carcinogens that may play a role in the oncogenesis of penile cancer. Objectives: To investigate the role of HPV infection and expression of the ... -
Ig isotype switching in B lymphocytes : A method for estimating isotype switch frequency in cloned B cell lymphomas
Whitmore, A. C.; Prowse, David M.; Arnold, L. W.; Haughton, G. (1989)We have developed a method for enumerating the frequency of Ig isotype switching in clones of B cells. The method adapts Poisson statistics to analyze the distribution of amounts of switched isotype produced by multiple ... -
Ig isotype switching in B lymphocytes : The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma
Whitmore, A. C.; Prowse, David M.; Haughton, G.; Arnold, L. W. (1991)The murine B cell lymphoma CH12.LX, which bears cell surface IgM specific for the phosphatidyl choline epitope of sheep red blood cells, is capable of spontaneous isotype switching in vitro. Switching to IgG3, IgG1, IgG2b, ... -
Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer
Kudahetti, Sakunthala C.; Fisher, Gabrielle; Ambroisine, Laurence; Prowse, David M.; Kattan, Michael W.; Foster, Christopher S.; Møller, Henrik; Oliver, Tim; Fletcher, Anne; Cooper, Colin; Reuter, Victor; Scardino, Peter; Cuzick, Jack; Berney, Daniel M. (2010-10-01)Aims: Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle ... -
Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling
Shaw, Greg; Prowse, David M. (2008-03-18)Background: Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged ... -
International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients
Shaw, Greg L.; Wilson, Peter; Cuzick, Jack; Prowse, David M.; Goldenberg, S. Larry; Spry, Nigel A.; Oliver, Tim (2007-05-01)OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a ... -
Involvement of the Sp3 transcription factor in induction of p21(Cip1/WAF1) in keratinocyte differentiation
Prowse, David M.; Bolgan, Loretta; Molnár, Árpád; Dotto, G. Paolo (1997-01-25)The cyclin-dependent kinase inhibitor p21 is induced in several in vitro terminal differentiation systems as well as in differentiating tissues in vivo. To determine the mechanism responsible for p21 induction during ...