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Browsing by Author "Rose, Sarah"
Now showing items 1-15 of 15
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The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Tel, Banu C.; Rose, Sarah; Schapira, Anthony H.; Jenner, Peter (2008-08)The D2/D3 dopamine receptor agonist pramipexole, protects against toxin-induced dopaminergic neuronal destruction but its mechanism of action is unknown. Inflammation following glial cell activation contributes to cell ... -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate
Coletto, Erika; Tough, Ian; Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Jenner, Peter; Chaudhuri, K. Ray; Cox, Helen; Iravani, Mahmoud; Rose, Sarah (2021-01-21)The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical ... -
The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression
Brzozowski, Monika J.; Alcantara, Susana Lopez; Iravani, Mahmoud M.; Rose, Sarah; Jenner, Peter (2011-08-02)Nitric oxide is linked with neurodegeneration in Parkinson's disease (PD) through the involvement of both inducible (iNOS) and neuronal nitric oxide synthase (nNOS). While nonselective NOS inhibitors are neuroprotective, ... -
The H3 receptor agonist immepip does not affect l-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned rats
Papathanou, Maria; Jenner, Peter; Iravani, Mahmoud M.; Jackson, Michael; Stockwell, Kim; Strang, Isobel; Zeng, Bai-Yun; McCreary, Andrew; Rose, Sarah (2014-10-15)The treatment of dyskinesia in Parkinson׳s disease remains poor but H3 receptor agonists have been suggested as a novel pharmacological approach. We examined the effects of the H3 agonist, immepip, in 6-OHDA-lesioned rats ... -
An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat
Bukhatwa, Salma; Iravani, Mahmoud M.; Zeng, Bai-Yun; Cooper, Jonathan D.; Rose, Sarah; Jenner, Peter (2009-04)Systemic administration of the proteasomal inhibitor I (PSI) to rats was reported to cause progressive nigral dopaminergic neuronal loss but this is disputed. A major controversy centres over the use of manual counting of ... -
Increase in the number of striatal neuronal nitric oxide synthase immunoreactive (nNOS-ir) interneurones in MPTP-treated common marmosets primed for and displaying levodopa-induced dyskinesia
Peeris, Megawate; Geraldes, Luiza; Jackson, Michael; Hikima, Atsuko; Broadstock, Martin; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M. (2013)In Parkinson’s disease (PD), dyskinesia is a consequence of nigral dopaminergic cell death and chronic levodopa treatment. The cause of levodopa-induced dyskinesia (LID) is unknown but may result from adaptive neuronal ... -
Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Jenner, Peter; Rose, Sarah (2012-02-29)Reactive gliosis and inflammatory change is a key component of nigral dopaminergic cell death in Parkinson's disease (PD). Astrocyte derived glial cell line-derived neurotrophic factor (GDNF) promotes the survival and ... -
Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss
Iravani, Mahmoud M.; Sadeghian, Mona; Rose, Sarah; Jenner, Peter (2014-12-01)In Parkinson's disease (PD), destruction of noradrenergic neurons in the locus coeruleus (LC) may precede damage to nigral cells and subsequently exaggerate dopaminergic cell loss. We examine if destruction of the locus ... -
Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease
Modo, Michel; Crum, William R; Gerwig, Madeline; Vernon, Anthony C; Patel, Priya; Jackson, Michael J; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M (2017-07-24)Parkinson's disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is ... -
Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
Zeng, Bai-Yun; Iravani, Mahmoud M.; Jackson, Michael J.; Rose, Sarah; Parent, Andre; Jenner, Peter (2010-12)Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed ... -
Physiological and Functional Changes in the Colon of MPTP-Treated Common Marmosets
Coletto, Erika; Tough, Ian; Hikima, Atsuko; Iravani, Mahmoud M.; Chaudhuri, K. Ray; Jenner, Peter; Cox, Helen; Rose, Sarah (2014-05)Objective: To determine changes in colon pathophysiology in MPTP-treated common marmosets. Background: Constipation is a common premotor symptom of Parkinson's disease (PD) and may be the result of changes in colonic ... -
The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)
Pritchard, Sara; Jackson, Michael; Lione, Lisa; Benham, Christopher; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M. (2013-12)Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common ...