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Browsing by Author "Sahakian, Barbara J."
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Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder
Gillan, Claire M.; Papmeyer, Martina; Morein-Zamir, Sharon; Sahakian, Barbara J.; Fineberg, Naomi; Robbins, Trevor W.; de Wit, Sanne (2011-07)Objective: Obsessive-compulsive disorder (OCD) is characterized by repetitive, ritualistic behaviors and thought patterns. Although patients with OCD report that these compulsive behaviors are unproductive and often ... -
Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder
Murray, Graham; Knolle, Franziska; Ersche, Karen D; Craig, Kevin J; Abbott, Sanja; Shabbir, Shaila S; Fineberg, Naomi; Suckling, John; Sahakian, Barbara J.; Bullmore, Edward T.; Robbins, Trevor W. (2019-08-01)Rationale: Patients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior ... -
Gambling disorder in the UK: key research priorities and the urgent need for independent research funding
Bowden-Jones, Henrietta; Hook, Roxanne; Grant, Jon E; Ioannidis, Konstantinos; Corazza, Ornella; Fineberg, Naomi; Singer, Bryan; Roberts, Amanda; Bethlehem, Richard; Dymond, Simon; Romero-Garcia, Rafael; Robbins, Trevor; Cortese, Samuele; Thomas, Shane; Sahakian, Barbara J.; Dowling, Nicki; Chamberlain, Samuel R. (2022-04-15)Gambling in the modern era is pervasive owing to the variety of gambling opportunities available, including those that use technology (eg, online applications on smartphones). Although many people gamble recreationally ... -
Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder
Apergis-Schoute, Annemieke M; Bijleveld, Bastiaan; Gillan, Claire M.; Fineberg, Naomi; Sahakian, Barbara J. (2018-11-30)Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive ... -
Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder
Vaghi, Matilde M.; Hampshire, Adam; Kaser, Muzaffer; Fineberg, Naomi; Brühl, Annette B.; Sahakian, Barbara J.; Chamberlain, Samuel R.; Robbins, Trevor W. (2017-11-01)Background The symptoms of obsessive-compulsive disorder (OCD) have been postulated to result from impaired executive functioning and excessive habit formation at the expense of goal-directed control and have been objectively ... -
Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder
Hampshire, Adam; Zadel, Ana; Sandrone, Stefano; Soreq, Eyal; Fineberg, Naomi; Bullmore, Edward T.; Robbins, Trevor W.; Sahakian, Barbara J.; Chamberlain, Samuel R. (2020-02)BACKGROUND: Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric condition, with biological models implicating disruption of cortically mediated inhibitory control pathways, ordinarily serving to regulate ... -
Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search
Morein-Zamir, Sharon; Papmeyer, Martina; Durieux, Alice; Fineberg, Naomi A.; Sahakian, Barbara J.; Robbins, Trevor W. (2013-11-08)Whether Obsessive Compulsive Disorder (OCD) is associated with an increased attentional bias to emotive stimuli remains controversial. Additionally, it is unclear whether comorbid depression modulates abnormal emotional ... -
Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders : Cognitive Domains, Neural Circuitry, and Treatment
Fineberg, Naomi A.; Apergis-Schoute, Annemieke M.; Vaghi, Matilde M.; Banca, Paula; Gillan, Claire M.; Voon, Valerie; Chamberlain, Samuel R.; Cinosi, Eduardo; Reid, Jemma; Shahper, Sonia; Bullmore, Edward T.; Sahakian, Barbara J.; Robbins, Trevor W. (2018-01-01)Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioral inhibition (motor inhibition, cognitive inflexibility) ... -
Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication
Apergis-Schoute, Annemieke M.; van der Flier, Febe E.; Ip, Samantha H.Y.; Kanen, Jonathan W.; Vaghi, Matilde M.; Fineberg, Naomi A.; Sahakian, Barbara J.; Cardinal, Rudolf N; Robbins, Trevor W. (2024-01-16)Background The nature of cognitive flexibility deficits in obsessive-compulsive disorder (OCD), which historically have been tested with probabilistic reversal learning tasks, remains elusive. Here, a novel deterministic ... -
Set-shifting related basal ganglia deformation as a novel familial marker of obsessive-compulsive disorder
Isobe, Masanori; Vaghi, Matilde M.; Fineberg, Naomi; Apergis-Schoute, Annemieke M.; Bullmore, Edward T.; Sahakian, Barbara J.; Robbins, Trevor; Chamberlain, Samuel R. (2021-04-21)The symptoms of obsessive-compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to ... -
The size, burden and cost of disorders of the brain in the UK
Fineberg, Naomi; Haddad, Peter M.; Carpenter, Lewis; Gannon, Brenda; Sharpe, Rachel; Young, Allan H.; Joyce, Eileen; Rowe, James; Wellsted, D.; Nutt, David J.; Sahakian, Barbara J. (2013-09)Aim: The aim of this paper is to increase awareness of the prevalence and cost of psychiatric and neurological disorders (brain disorders) in the UK. Method: UK data for 18 brain disorders were extracted from a systematic ...