Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model
Author
Baines, Simon D.
O'Connor, Rachel
Saxton, Katie
Freeman, Jane
Wilcox, M. H.
Attention
2299/10121
Abstract
Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.