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dc.contributor.authorKinabo, L. D.
dc.contributor.authorMcKellar, Quintin
dc.contributor.authorMurray, M.
dc.date.accessioned2013-07-02T07:32:01Z
dc.date.available2013-07-02T07:32:01Z
dc.date.issued1989
dc.identifier.citationKinabo , L D , McKellar , Q & Murray , M 1989 , ' Determination of halofuginone in bovine plasma by competing-ion high performance liquid chromatography after solid phase extraction ' , Biomedical Chromatography , vol. 3 , no. 3 , pp. 136-8 . https://doi.org/10.1002/bmc.1130030310
dc.identifier.issn0269-3879
dc.identifier.otherPURE: 1445733
dc.identifier.otherPURE UUID: d1c146bb-9b2c-4cfb-8264-85f27edb809c
dc.identifier.otherPubMed: 2765695
dc.identifier.otherScopus: 0024335575
dc.identifier.urihttp://hdl.handle.net/2299/10984
dc.description.abstractA high performance liquid chromatography (HPLC) method for the determination of the anticoccidial and antitheilerial drug halofuginone in bovine plasma was developed. Samples were diluted with acetic acid (10%, v/v) and cleaned up on a Bond Elut C8 column. The analyte was eluted from the extraction column and chromatographed by reversed-phase HPLC using decylamine as a competing-ion reagent. Detection was by UV at 243 nm. Recovery from plasma was 75%, and within-day and between-day coefficients of variation were 5.23 and 6.35% respectively. The specificity and sensitivity of this method (limit of detection in plasma, 1 ng/mL) were sufficiently high to enable us to characterize the time course of the drug in plasma after oral administration of therapeutic doses to cattle.en
dc.format.extent3
dc.language.isoeng
dc.relation.ispartofBiomedical Chromatography
dc.titleDetermination of halofuginone in bovine plasma by competing-ion high performance liquid chromatography after solid phase extractionen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
dcterms.dateAccepted1989
rioxxterms.versionofrecordhttps://doi.org/10.1002/bmc.1130030310
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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