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dc.contributor.authorAli, B.H.
dc.contributor.authorCheng, Z.
dc.contributor.authorHadrami, G.
dc.contributor.authorBashir, A.K.
dc.contributor.authorMcKellar, Quintin
dc.date.accessioned2013-07-25T12:02:43Z
dc.date.available2013-07-25T12:02:43Z
dc.date.issued1996-06
dc.identifier.citationAli , B H , Cheng , Z , Hadrami , G , Bashir , A K & McKellar , Q 1996 , ' Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats ' Journal of Veterinary Pharmacology and Therapeutics , vol. 19 , no. 3 , pp. 238-244 . https://doi.org/10.1111/j.1365-2885.1996.tb00044.x
dc.identifier.otherPURE: 1426747
dc.identifier.otherPURE UUID: e6a62eed-e4b1-450a-bdce-df4db08bb1c6
dc.identifier.otherBibtex: urn:9d3450be8f69ed48681ee426a657050c
dc.identifier.otherScopus: 0029898703
dc.identifier.urihttp://hdl.handle.net/2299/11180
dc.description.abstractParacetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 +/- 1.4 ml/mL . kg vs, 52.8 +/- 7.3 mL/min . kg) (P < 0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 +/- 0.50 vs. 6.59 +/- 0.51 following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.39% of that of the glucuronide conjugate. The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 +/- 17% in goats and 105 +/- 26% in camels.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.subjectSHEEP
dc.subjectTISSUES
dc.subjectEXCRETION
dc.subjectSWINE
dc.subjectRATS
dc.subjectACID
dc.titleComparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goatsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1365-2885.1996.tb00044.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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