Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model

Abstract

Data on the risk of Clostridium difficile infection (CDI) associated with specific antibiotics are difficult to obtain because of confounding clinical factors. It is particularly important to evaluate the propensity of new antibiotics to induce CDI. We have examined the propensity of tigecycline to induce CDI using a human gut model.