CCR2B receptor antagonists : Conversion of a weak HTS hit to a potent lead compound
Author
Forbes, Ian T.
Cooper, David G.
Dodds, Emma K.
Hickey, Deirdre M. B.
Ife, Robert J.
Meeson, Malcolm
Stockley, Martin
Berkhout, Theo
Gohil, Jayneeta
Groot, Pieter H. E.
Moores, Kitty E.
Attention
2299/13701
Abstract
A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.