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        Diminished 11 Beta-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life.

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        Author
        Rogers, Samantha
        Hughes, Beverly A.
        Jones, Christopher A.
        Freedman, Lauren
        Smart, Katherine
        Taylor, Norman
        Stewart, Paul M.
        Shackleton, Cedric H.L.
        Krone, Nils P.
        Blissett, Jacqueline
        Tomlinson, Jeremy W.
        Attention
        2299/14902
        Abstract
        Objective: We have hypothesized that changes in GC metabolism leading to increased availability may impair growth. Design: This was a prospective, longitudinal study with clinical measurements and 24-hour urinary steroid metabolite analysis at 1, 4, 12, 26, and 52 weeks after delivery in mothers and their babies. Setting: The study was conducted with observations and samples collected in the volunteers’ own homes. Participants: Healthy mothers and newborn babies/infants participated in the study. Interventions: There were no interventions. Main outcome measures: Urinary steroid metabolite excretion quantified by gas chromatography/ mass spectroscopy across the first year of life in relation to change in weight was measured. Results: The total production of the GC metabolites quantified increased across the first year of life. Markers of 11ﰀ-hydroxysteroid dehydrogenase type 1 activity increased from the age of 3 months as did those of 5ﰂ-reductase activity. After correcting for confounding variables, low markers of 11ﰀ-hydroxysteroid dehydrogenase type 2 activity was associated with reduced absolute weight and decreased weight gain over the first year of life. In the mothers, 5ﰂ-reductase activity was low at birth and progressively increased to normal over the first 6 months postpartum. Conclusions: Increased GC exposure as a consequence of reduced 11ﰀ-hydroxysteroid dehydro- genase type 2 activity is likely to be a critical determinant of growth in early life. This not only highlights the central role of GCs and their metabolism, but also emphasizes the need for detailed longitudinal analyses.
        Publication date
        2014-05-01
        Published in
        Journal of Clinical Endocrinology and Metabolism
        Published version
        https://doi.org/10.1210/jc.2013-3254
        Other links
        http://hdl.handle.net/2299/14902
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        School of Life and Medical Sciences
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