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        Synthesis of mucoadhesive thiol-bearing microgels from 2-(acetylthio) ethylacrylate and 2-hydroxyethylmethacrylate : novel drug delivery systems for chemotherapeutic agents to the bladder

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        c5tb00834d.pdf (PDF, 1Mb)
        Author
        Cook, Michael T.
        Schmidt, S.A.
        Lee, E.
        Samprasit, W.
        Opanasopit, P.
        Khutoryanskiy, Vitaliy V.
        Attention
        2299/16268
        Abstract
        Thiol-bearing microgels have been synthesised from copolymerisation of 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate, and subsequent deprotection using sodium thiomethoxide. The concentration of thiol groups on these microgels could be tailored by use of different molar ratios of the two monomers. These thiol-bearing microgels were shown to adhere to ex vivo porcine urinary bladder, which was correlated with their level of thiolation. By simply mixing solutions of thiol-bearing microgels and doxorubicin, high levels of drug loading into the microgels could be achieved. Thiol-bearing microgels controlled the release of doxorubicin in a time-dependent manner over several hours. These doxorubicin-loaded thiol-bearing microgels could have application in the treatment of early-stage bladder cancers. The method used represents a new ‘bottom-up’ approach for the synthesis of novel mucoadhesive microgels
        Publication date
        2015-07-21
        Published in
        Journal of Materials Chemistry B
        Published version
        https://doi.org/10.1039/C5TB00834D
        Other links
        http://hdl.handle.net/2299/16268
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