dc.contributor.author | Cook, Michael T. | |
dc.contributor.author | Schmidt, S.A. | |
dc.contributor.author | Lee, E. | |
dc.contributor.author | Samprasit, W. | |
dc.contributor.author | Opanasopit, P. | |
dc.contributor.author | Khutoryanskiy, Vitaliy V. | |
dc.date.accessioned | 2015-08-18T08:58:37Z | |
dc.date.available | 2015-08-18T08:58:37Z | |
dc.date.issued | 2015-07-21 | |
dc.identifier.citation | Cook , M T , Schmidt , S A , Lee , E , Samprasit , W , Opanasopit , P & Khutoryanskiy , V V 2015 , ' Synthesis of mucoadhesive thiol-bearing microgels from 2-(acetylthio) ethylacrylate and 2-hydroxyethylmethacrylate : novel drug delivery systems for chemotherapeutic agents to the bladder ' , Journal of Materials Chemistry B , vol. 3 , no. 32 , pp. 6599-6604 . https://doi.org/10.1039/C5TB00834D | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.other | PURE: 9063320 | |
dc.identifier.other | PURE UUID: 62be3dd4-6873-418f-a5fd-158db178236b | |
dc.identifier.other | Scopus: 84938723333 | |
dc.identifier.uri | http://hdl.handle.net/2299/16268 | |
dc.description | This is an Open Access article is licensed under a Creative Commons Attribution 3.0 Unported Licence | |
dc.description.abstract | Thiol-bearing microgels have been synthesised from copolymerisation of 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate, and subsequent deprotection using sodium thiomethoxide. The concentration of thiol groups on these microgels could be tailored by use of different molar ratios of the two monomers. These thiol-bearing microgels were shown to adhere to ex vivo porcine urinary bladder, which was correlated with their level of thiolation. By simply mixing solutions of thiol-bearing microgels and doxorubicin, high levels of drug loading into the microgels could be achieved. Thiol-bearing microgels controlled the release of doxorubicin in a time-dependent manner over several hours. These doxorubicin-loaded thiol-bearing microgels could have application in the treatment of early-stage bladder cancers. The method used represents a new ‘bottom-up’ approach for the synthesis of novel mucoadhesive microgels | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Materials Chemistry B | |
dc.title | Synthesis of mucoadhesive thiol-bearing microgels from 2-(acetylthio) ethylacrylate and 2-hydroxyethylmethacrylate : novel drug delivery systems for chemotherapeutic agents to the bladder | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.description.status | Peer reviewed | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | https://doi.org/10.1039/C5TB00834D | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |