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        Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

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        900026.pdf (PDF, 88Kb)
        Author
        Wileman, S.M.
        Mann, G.E.
        Baydoun, A. R.
        Attention
        2299/1704
        Abstract
        The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.
        Publication date
        1995
        Published in
        British Journal of Pharmacology
        Other links
        http://hdl.handle.net/2299/1704
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