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        The impact of MTHFR 677C → T risk knowledge on changes in folate intake : findings from the Food4Me study

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        Author
        O'Donovan, Clare B
        Walsh, Marianne C
        Forster, Hannah
        Woolhead, Clara
        Celis-Morales, Carlos
        Fallaize, Rosalind
        Macready, Anna L
        Marsaux, Cyril F M
        Navas-Carretero, Santiago
        San-Cristobal, Rodrigo
        Kolossa, Silvia
        Mavrogianni, Christina
        Lambrinou, Christina P
        Moschonis, George
        Godlewska, Magdalena
        Surwillo, Agnieszka
        Bouwman, Jildau
        Grimaldi, Keith
        Traczyk, Iwona
        Drevon, Christian A
        Daniel, Hannelore
        Manios, Yannis
        Martinez, J Alfredo
        Saris, Wim H M
        Lovegrove, Julie A
        Mathers, John C
        Gibney, Michael J
        Brennan, Lorraine
        Gibney, Eileen R
        Attention
        2299/17454
        Abstract
        BACKGROUND: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. RESULTS: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 ± 172, 391 ± 190 and 410 ± 186 μg per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. CONCLUSIONS: These results suggest that knowledge of MTHFR 677C → T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant. TRIAL REGISTRATION: ClinicalTrials.gov NCT01530139.
        Publication date
        2016-09-29
        Published in
        Genes and Nutrition
        Published version
        https://doi.org/10.1186/s12263-016-0539-x
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/17454
        Relations
        School of Life and Medical Sciences
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