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dc.contributor.authorBass, Chris
dc.contributor.authorDenholm, Ian
dc.contributor.authorWilliamson, MS
dc.contributor.authorNauen, Ralf
dc.date.accessioned2017-09-04T17:03:05Z
dc.date.available2017-09-04T17:03:05Z
dc.date.issued2015-06-30
dc.identifier.citationBass , C , Denholm , I , Williamson , MS & Nauen , R 2015 , ' The global status of insect resistance to neonicotinoid insecticides ' , Pesticide Biochemistry and Physiology , vol. 121 , pp. 78-87 . https://doi.org/10.1016/j.pestbp.2015.04.004
dc.identifier.issn0048-3575
dc.identifier.otherPURE: 10518188
dc.identifier.otherPURE UUID: 15346f0f-9fcb-4acc-84cd-ef5a6d60f164
dc.identifier.otherScopus: 84930374199
dc.identifier.otherORCID: /0000-0001-9797-874X/work/62750679
dc.identifier.urihttp://hdl.handle.net/2299/19307
dc.descriptionThis document is the Accepted Manuscript version of the following article: Chris Bass, Ian Denholm, Martin S. Williamson, and Ralf Nauen, ‘The global status of insect resistance to neonicotinoid insecticides’, Pesticide Biochemistry and Physiology, Vol. 121, pp. 78-87, June 2015. The Version of Record is available online at doi: https://doi.org/10.1016/j.pestbp.2015.04.004. Published by Elsevier Copyright © 2015 Elsevier Inc.
dc.description.abstractThe first neonicotinoid insecticide, imidacloprid, was launched in 1991. Today this class of insecticides comprises at least seven major compounds with a market share of more than 25% of total global insecticide sales. Neonicotinoid insecticides are highly selective agonists of insect nicotinic acetylcholine receptors and provide farmers with invaluable, highly effective tools against some of the world's most destructive crop pests. These include sucking pests such as aphids, whiteflies, and planthoppers, and also some coleopteran, dipteran and lepidopteran species. Although many insect species are still successfully controlled by neonicotinoids, their popularity has imposed a mounting selection pressure for resistance, and in several species resistance has now reached levels that compromise the efficacy of these insecticides. Research to understand the molecular basis of neonicotinoid resistance has revealed both target-site and metabolic mechanisms conferring resistance. For target-site resistance, field-evolved mutations have only been characterized in two aphid species. Metabolic resistance appears much more common, with the enhanced expression of one or more cytochrome P450s frequently reported in resistant strains. Despite the current scale of resistance, neonicotinoids remain a major component of many pest control programmes, and resistance management strategies, based on mode of action rotation, are of crucial importance in preventing resistance becoming more widespread. In this review we summarize the current status of neonicotinoid resistance, the biochemical and molecular mechanisms involved, and the implications for resistance management.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofPesticide Biochemistry and Physiology
dc.rightsEmbargoed
dc.subjectAgricultural and Biological Sciences(all)
dc.titleThe global status of insect resistance to neonicotinoid insecticidesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionCrop Protection and Climate Change
dc.contributor.institutionEcology
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-06-01
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2015-06-30
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.pestbp.2015.04.004
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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