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        Endogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risk

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        Endogenous_Fibrinolysis.pdf (PDF, 1Mb)
        Author
        Okafor, Osita N
        Gorog, Diana A
        Attention
        2299/21326
        Abstract
        Most acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously activating enzymatic processes that mediate endogenous fibrinolysis to physiologically maintain vessel patency. Interplay between these pathways determines clinical outcome. If proaggregatory factors predominate, the thrombus may propagate, leading to vessel occlusion. However, if balanced by a healthy fibrinolytic system, thrombosis may not occur or cause lasting occlusion. Despite abundant evidence for the fibrinolytic system regulating thrombosis, it has been overlooked compared with platelet reactivity, partly due to a lack of techniques to measure it. We evaluate evidence for endogenous fibrinolysis in arterial thrombosis and review techniques to assess it, including biomarkers and global assays, such as thromboelastography and the Global Thrombosis Test. Global assays, simultaneously assessing proaggregatory and fibrinolytic pathways, could play a role in risk stratification and in identifying impaired fibrinolysis as a potential target for pharmacological modulation.
        Publication date
        2015-04-28
        Published in
        Journal of the American College of Cardiology
        Published version
        https://doi.org/10.1016/j.jacc.2015.02.040
        Other links
        http://hdl.handle.net/2299/21326
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