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        Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

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        Author
        Madeira do O, J.
        Foralosso, R.
        Yilmaz, G.
        Mastrotto, F.
        King, P.J.S.
        Xerri, R.M.
        He, Y.
        van der Walle, C.F.
        Fernandez-Trillo, F.
        Laughton, C. A.
        Styliari, Ioanna Danai
        Stolnik, S.
        Mantovani, G.
        Attention
        2299/21868
        Abstract
        Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques-DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis-and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.
        Publication date
        2019-10-29
        Published in
        Nanoscale
        Published version
        https://doi.org/10.1039/C9NR05836B
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/21868
        Relations
        School of Life and Medical Sciences
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