dc.contributor.author | Madeira do O, J. | |
dc.contributor.author | Foralosso, R. | |
dc.contributor.author | Yilmaz, G. | |
dc.contributor.author | Mastrotto, F. | |
dc.contributor.author | King, P.J.S. | |
dc.contributor.author | Xerri, R.M. | |
dc.contributor.author | He, Y. | |
dc.contributor.author | van der Walle, C.F. | |
dc.contributor.author | Fernandez-Trillo, F. | |
dc.contributor.author | Laughton, C. A. | |
dc.contributor.author | Styliari, Ioanna Danai | |
dc.contributor.author | Stolnik, S. | |
dc.contributor.author | Mantovani, G. | |
dc.date.accessioned | 2019-11-08T01:21:00Z | |
dc.date.available | 2019-11-08T01:21:00Z | |
dc.date.issued | 2019-10-29 | |
dc.identifier.citation | Madeira do O , J , Foralosso , R , Yilmaz , G , Mastrotto , F , King , P J S , Xerri , R M , He , Y , van der Walle , C F , Fernandez-Trillo , F , Laughton , C A , Styliari , I D , Stolnik , S & Mantovani , G 2019 , ' Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers ' , Nanoscale , vol. 11 , no. 44 , pp. 21155-21166 . https://doi.org/10.1039/C9NR05836B | |
dc.identifier.issn | 2040-3364 | |
dc.identifier.other | ORCID: /0000-0002-7476-2994/work/64327947 | |
dc.identifier.uri | http://hdl.handle.net/2299/21868 | |
dc.description | © The Royal Society of Chemistry 2019. | |
dc.description.abstract | Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques-DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis-and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery. | en |
dc.format.extent | 12 | |
dc.format.extent | 4405969 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nanoscale | |
dc.subject | General Materials Science | |
dc.title | Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers | en |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85074965474&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1039/C9NR05836B | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |