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dc.contributor.authorMadeira do O, J.
dc.contributor.authorForalosso, R.
dc.contributor.authorYilmaz, G.
dc.contributor.authorMastrotto, F.
dc.contributor.authorKing, P.J.S.
dc.contributor.authorXerri, R.M.
dc.contributor.authorHe, Y.
dc.contributor.authorvan der Walle, C.F.
dc.contributor.authorFernandez-Trillo, F.
dc.contributor.authorLaughton, C. A.
dc.contributor.authorStyliari, Ioanna Danai
dc.contributor.authorStolnik, S.
dc.contributor.authorMantovani, G.
dc.date.accessioned2019-11-08T01:21:00Z
dc.date.available2019-11-08T01:21:00Z
dc.date.issued2019-10-29
dc.identifier.citationMadeira do O , J , Foralosso , R , Yilmaz , G , Mastrotto , F , King , P J S , Xerri , R M , He , Y , van der Walle , C F , Fernandez-Trillo , F , Laughton , C A , Styliari , I D , Stolnik , S & Mantovani , G 2019 , ' Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers ' , Nanoscale , vol. 11 , no. 44 , pp. 21155-21166 . https://doi.org/10.1039/C9NR05836B
dc.identifier.issn2040-3364
dc.identifier.otherPURE: 17364690
dc.identifier.otherPURE UUID: f7ee4e87-3188-4fca-bcf4-037c18b2dccc
dc.identifier.otherORCID: /0000-0002-7476-2994/work/64327947
dc.identifier.otherScopus: 85074965474
dc.identifier.urihttp://hdl.handle.net/2299/21868
dc.description© The Royal Society of Chemistry 2019.
dc.description.abstractSynthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques-DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis-and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofNanoscale
dc.rightsOpen
dc.subjectMaterials Science(all)
dc.titlePoly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriersen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85074965474&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-10-29
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1039/C9NR05836B
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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