dc.contributor.author | Ryan, Sean G. | |
dc.contributor.author | Butler, Matthew N. | |
dc.contributor.author | Adeyemi, Segun | |
dc.contributor.author | Kalber, Tammy | |
dc.contributor.author | Patrick, Peter Stephen | |
dc.contributor.author | Thin, May Zaw | |
dc.contributor.author | Harrison, Ian F. | |
dc.contributor.author | Stuckey, Daniel J. | |
dc.contributor.author | Pule, Martin | |
dc.contributor.author | Lythgoe, Mark | |
dc.date.accessioned | 2019-12-17T01:07:39Z | |
dc.date.available | 2019-12-17T01:07:39Z | |
dc.date.issued | 2019-12-16 | |
dc.identifier.citation | Ryan , S G , Butler , M N , Adeyemi , S , Kalber , T , Patrick , P S , Thin , M Z , Harrison , I F , Stuckey , D J , Pule , M & Lythgoe , M 2019 , ' Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse ' , Scientific Reports , vol. 9 , no. 1 , 19223 . https://doi.org/10.1038/s41598-019-55769-5 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | ORCID: /0000-0001-9069-5122/work/66369084 | |
dc.identifier.uri | http://hdl.handle.net/2299/22010 | |
dc.description | © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.description.abstract | Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible. | en |
dc.format.extent | 10 | |
dc.format.extent | 2348169 | |
dc.format.extent | 11359306 | |
dc.format.extent | 2432 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | |
dc.subject | X-ray imaging | |
dc.subject | quantum dots | |
dc.subject | nanoparticles | |
dc.subject | biosensors | |
dc.subject | nanobiotechnology | |
dc.subject | optical imaging | |
dc.subject | Radiological and Ultrasound Technology | |
dc.subject | Biochemistry, medical | |
dc.subject | Microbiology (medical) | |
dc.subject | Physiology (medical) | |
dc.subject | Radiology Nuclear Medicine and imaging | |
dc.subject | Instrumentation | |
dc.subject | Radiation | |
dc.title | Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse | en |
dc.contributor.institution | School of Physics, Astronomy and Mathematics | |
dc.contributor.institution | School of Health and Social Work | |
dc.contributor.institution | Centre for Astrophysics Research | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85076618682&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1038/s41598-019-55769-5 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |