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        Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA

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        v21i4p152.pdf (PDF, 142Kb)
        Author
        Pisarska, Agnieszka
        Deluca, Paolo
        Demetrovics, Zsolt
        Corkery, John
        Moskalewicz, Jacek
        ReDNet Group
        Corazza, Ornella
        Corkery, John
        Stair, Jacqueline
        Fergus, Suzanne
        Pezzolesi, Cinzia
        Schifano, Fabrizio
        Attention
        2299/22450
        Abstract
        Dopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of schizophrenia) differs from the other two partial agonist antipsychotics aripiprazole and brexpiprazole due to its unique features. Cariprazine is a dopamine D 3 preferring D 3/D2 partial agonist with very similar dopamine receptor sub-type selectivity as dopamine. It has proven efficacy in the treatment of positive and negative symptoms of schizophrenia, as well as for relapse prevention. Further phase-3 clinical studies proved the efficacy of cariprazine in the acute treatment of manic or mixed episodes associated with bipolar I disorder, as well as in bipolar depression. For the adjunctive treatment of major depressive disorder, phase 3 studies are in progress.
        Publication date
        2020-02-18
        Published in
        Neuropsychopharmacologia Hungarica
        Other links
        http://hdl.handle.net/2299/22450
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