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dc.contributor.authorPisarska, Agnieszka
dc.contributor.authorDeluca, Paolo
dc.contributor.authorDemetrovics, Zsolt
dc.contributor.authorCorkery, John
dc.contributor.authorMoskalewicz, Jacek
dc.contributor.authorReDNet Group
dc.contributor.authorCorazza, Ornella
dc.contributor.authorCorkery, John
dc.contributor.authorStair, Jacqueline
dc.contributor.authorFergus, Suzanne
dc.contributor.authorPezzolesi, Cinzia
dc.contributor.authorSchifano, Fabrizio
dc.date.accessioned2020-03-22T01:20:42Z
dc.date.available2020-03-22T01:20:42Z
dc.date.issued2020-02-18
dc.identifier.citationPisarska , A , Deluca , P , Demetrovics , Z , Corkery , J , Moskalewicz , J , ReDNet Group , , Corazza , O , Corkery , J , Stair , J , Fergus , S , Pezzolesi , C & Schifano , F 2020 , ' Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA ' , Neuropsychopharmacologia Hungarica , vol. 21 , no. 3 , pp. 152-163 .
dc.identifier.issn1419-8711
dc.identifier.otherPURE: 17827973
dc.identifier.otherPURE UUID: 5d3d85c0-3193-4530-b782-6f6a53d1dcd9
dc.identifier.otherScopus: 85072393129
dc.identifier.otherORCID: /0000-0002-7134-0665/work/70885847
dc.identifier.otherORCID: /0000-0001-7371-319X/work/98163899
dc.identifier.urihttp://hdl.handle.net/2299/22450
dc.descriptionSubmitted 19 September 2019; Accepted 29 November 2019; Proof received 29 November 2019; Published 18 February 2020. Note: No DOI allocated.
dc.description.abstractDopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of schizophrenia) differs from the other two partial agonist antipsychotics aripiprazole and brexpiprazole due to its unique features. Cariprazine is a dopamine D 3 preferring D 3/D2 partial agonist with very similar dopamine receptor sub-type selectivity as dopamine. It has proven efficacy in the treatment of positive and negative symptoms of schizophrenia, as well as for relapse prevention. Further phase-3 clinical studies proved the efficacy of cariprazine in the acute treatment of manic or mixed episodes associated with bipolar I disorder, as well as in bipolar depression. For the adjunctive treatment of major depressive disorder, phase 3 studies are in progress.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofNeuropsychopharmacologia Hungarica
dc.rightsOpen
dc.subjectnovel psychoactive substances
dc.subjectdrugs
dc.subjectaddiction
dc.subjectdelegalisation
dc.subjectinternational study
dc.subjectPredominant negative symptoms
dc.subjectAtypical antipsychotic
dc.subjectCariprazine
dc.subjectSchizophrenia
dc.subjectDopamine D and D receptor partial agonist
dc.subjectClinical Neurology
dc.subjectNeuropsychology and Physiological Psychology
dc.subjectNeuroscience(all)
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.titleNovel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USAen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85072393129&partnerID=8YFLogxK
dc.identifier.urlhttp://mppt-nph.hu/images/magazin/pdf/vol21issue4/v21i4p152.pdf
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2020-02-18
rioxxterms.versionVoR
rioxxterms.licenseref.uriUnspecified
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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