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dc.contributor.authorAdrian Martinez-Melendez, Adrian
dc.contributor.authorTijerina-Rodrıguez, Laura
dc.contributor.authorMorfin-Otero, Rayo
dc.contributor.authorCamacho-Ortiz, Adrian
dc.contributor.authorVillarreal-Trevino, Licet
dc.contributor.authorSanchez-Alanıs, Hugo
dc.contributor.authorRodrıguez-Noriega, Eduardo
dc.contributor.authorBaines, Simon
dc.contributor.authorFlores-Trevino, Samantha
dc.contributor.authorMaldonado-Garza, Hector Jesus
dc.contributor.authorGarza-Gonzalez, Elvira
dc.date.accessioned2020-03-26T01:05:56Z
dc.date.available2020-03-26T01:05:56Z
dc.date.issued2018-05-01
dc.identifier.citationAdrian Martinez-Melendez , A , Tijerina-Rodrıguez , L , Morfin-Otero , R , Camacho-Ortiz , A , Villarreal-Trevino , L , Sanchez-Alanıs , H , Rodrıguez-Noriega , E , Baines , S , Flores-Trevino , S , Maldonado-Garza , H J & Garza-Gonzalez , E 2018 , ' Circulation of Highly Drug-Resistant Clostridium difficile Ribotypes 027 and 001 in Two Tertiary-Care Hospitals in Mexico ' , Microbial Drug Resistance , vol. 24 , no. 4 , pp. 386-392 . https://doi.org/10.1089/mdr.2017.0323
dc.identifier.issn1931-8448
dc.identifier.otherPURE: 13597771
dc.identifier.otherPURE UUID: 522841ed-6923-4ef7-b724-148af6108ffd
dc.identifier.otherScopus: 85054460749
dc.identifier.urihttp://hdl.handle.net/2299/22495
dc.description© 2018, Mary Ann Liebert, Inc.
dc.description.abstractOBJECTIVE: To assess drug susceptibility and characterize Clostridium difficile ribotypes in isolates from two tertiary-care hospitals in Mexico. METHODS: Isolates were evaluated for genotyping, antimicrobial susceptibility testing and detection of mutations associated with drug resistance. PCR ribotyping was performed using a combination of gel-based and capillary electrophoresis-based approaches. RESULTS: MIC50 and MIC90 were ≥128 mg/L for ciprofloxacin, erythromycin, clindamycin, and rifampicin. There was no reduced susceptibility to metronidazole or tetracycline; however, reduced susceptibility to vancomycin (≥4 mg/L) and fidaxomicin (≥2 mg/L) was detected in 50 (40.3%) and 4 (3.2%) isolates, respectively. Furthermore, the rpoB Arg505Lys mutation was more frequently detected in isolates with high minimum inhibitory concentration (MIC) to rifampicin (≥32 mg/L) (OR = 52.5; 95% CI = 5.17-532.6; p < 0.000). Of the 124 C. difficile isolates recovered, 84 (66.7%) were of ribotype 027, 18 (14.5%) of ribotype 001, and the remainder were other ribotypes (353, 255, 220, 208, 176, 106, 076, 020, 019, 017, 014, 012, 003, and 002). CONCLUSION: Ribotypes 027 and 001 were the most frequent C. difficile isolates recovered in this study, and demonstrated higher MICs. Furthermore, we found four isolates with reduced susceptibility to fidaxomicin, raising a concern since this drug is currently unavailable in Mexican Hospitals.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofMicrobial Drug Resistance
dc.rightsEmbargoed
dc.subjectClostridium difficile
dc.subjectdrug resistance
dc.subjectfidaxomicin
dc.subjectribotype 001
dc.subjectribotypes
dc.subjectMicrobiology
dc.subjectImmunology
dc.subjectPharmacology
dc.subjectMicrobiology (medical)
dc.titleCirculation of Highly Drug-Resistant Clostridium difficile Ribotypes 027 and 001 in Two Tertiary-Care Hospitals in Mexicoen
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionMicrobiology and Biotechnology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionBiosciences Research Group
dc.description.statusPeer reviewed
dc.date.embargoedUntil2019-05-01
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85054460749&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2018-05-01
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1089/mdr.2017.0323
rioxxterms.licenseref.uriOther
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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