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        A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches

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        A_novel_treatment_strategy_for_preterm_birth_Intra_vaginal_progesterone_loaded_fibrous_patches.pdf (PDF, 26Mb)(embargoed until 19/08/2021)
        Author
        Emin Cam, Muhammet
        Nur Hazar-Yavuz, Ayse
        Cesur, Sumeyye
        Ozkan, Ozan
        Alenezi, Hussain
        Turkoglu Sasmazel, Hilal
        Sayip Eroglu, Mehmet
        Brako, Francis
        Ahmed, Jubair
        Kabasakal, Levent
        Ren, Guogang
        Gunduz, Oguzhan
        Edirisinghe, Mohan
        Attention
        2299/23656
        Abstract
        Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.
        Publication date
        2020-10-15
        Published in
        International Journal of Pharmaceutics
        Published version
        https://doi.org/10.1016/j.ijpharm.2020.119782
        Other links
        http://hdl.handle.net/2299/23656
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