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        Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

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        Author
        Singh, Kumar Saurabh
        Cordeiro, Erick M. G.
        Troczka, Bartlomiej J.
        Pym, Adam
        Mackisack, Joanna
        Mathers, Thomas C.
        Duarte, Ana
        Legeai, Fabrice
        Robin, Stéphanie
        Bielza, Pablo
        Burrack, Hannah J.
        Charaabi, Kamel
        Denholm, Ian
        Figueroa, Christian C.
        ffrench-Constant, Richard H.
        Jander, Georg
        Margaritopoulos, John T.
        Mazzoni, Emanuele
        Nauen, Ralf
        Ramírez, Claudio C.
        Ren, Guangwei
        Stepanyan, Ilona
        Umina, Paul A.
        Voronova, Nina V.
        Vontas, John
        Williamson, Martin S.
        Wilson, Alex C. C.
        Xi-Wu, Gao
        Youn, Young-Nam
        Zimmer, Christoph T.
        Simon, Jean-Christophe
        Hayward, Alex
        Bass, Chris
        Attention
        2299/25014
        Abstract
        Abstract: The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.
        Publication date
        2021-07-07
        Published in
        Communications Biology
        Published version
        https://doi.org/10.1038/s42003-021-02373-x
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/25014
        Relations
        School of Life and Medical Sciences
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