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dc.contributor.authorGorog, Diana
dc.contributor.authorGue, Ying X.
dc.contributor.authorChao, Tze-Fan
dc.contributor.authorFauchier, Laurent
dc.contributor.authorFerreiro, Jose Luis
dc.contributor.authorHuber, Kurt
dc.contributor.authorKonstantinidis, Stavros V
dc.contributor.authorLane, Deirdre A
dc.contributor.authorMarin, Francisco
dc.contributor.authorOldgren, Jonas
dc.contributor.authorPotpara, Tatjana
dc.contributor.authorRoldan, Vanessa
dc.contributor.authorRubboli, Andrea
dc.contributor.authorSibbing, Dirk
dc.contributor.authorTse, Hung-Fat
dc.contributor.authorVilahur, Gemma
dc.contributor.authorLip, Gregory Y H
dc.date.accessioned2022-06-01T13:15:01Z
dc.date.available2022-06-01T13:15:01Z
dc.date.issued2022-03-22
dc.identifier.citationGorog , D , Gue , Y X , Chao , T-F , Fauchier , L , Ferreiro , J L , Huber , K , Konstantinidis , S V , Lane , D A , Marin , F , Oldgren , J , Potpara , T , Roldan , V , Rubboli , A , Sibbing , D , Tse , H-F , Vilahur , G & Lip , G Y H 2022 , ' Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paper ' , Thrombosis and haemostasis . https://doi.org/10.1093/europace/euac020
dc.identifier.issn0340-6245
dc.identifier.urihttp://hdl.handle.net/2299/25543
dc.description© The Author(s) 2022. Published on behalf of the European Society of Cardiology. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1093/europace/euac020
dc.description.abstractWhilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of thromboembolism, major bleeding events (especially intracranial bleeds) may still occur and be devastating. The decision for initiating and continuing anticoagulation is often based on a careful assessment of both thromboembolism- and bleeding- risk. The more common and validated bleeding risk factors have been used to formulate bleeding risk stratification scores, but thromboembolism and bleeding risk factors often overlap. Also, many factors that increase bleeding risk are transient and modifiable, such as variable INR values, surgical procedures, vascular procedures, or drug-drug and food-drug interactions. Bleeding risk is also not a static ‘one off’ assessment based on baseline factors but is dynamic, being influenced by ageing, incident comorbidities and drug therapies. In this executive summary of our Consensus Document, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in patients with AF and VTE, with a view to summarising ‘best practice’ when approaching antithrombotic therapy in these patients. We address the epidemiology and size of the problem of bleeding risk in AF and VTE, and review established bleeding risk factors and summarise definitions of bleeding. Patient values and preferences, balancing the risk of bleeding against thromboembolism are reviewed, and the prognostic implications of bleeding are discussed. We propose consensus statements that may help to define evidence gaps and assist in everyday clinical practice.en
dc.format.extent28
dc.format.extent627981
dc.language.isoeng
dc.relation.ispartofThrombosis and haemostasis
dc.titleAssessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paperen
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.date.embargoedUntil2023-03-22
rioxxterms.versionofrecord10.1093/europace/euac020
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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