dc.contributor.author | Pantelidou, Maria | |
dc.contributor.author | Caglic, Iztok | |
dc.contributor.author | George, Anne | |
dc.contributor.author | Blyuss, Oleg | |
dc.contributor.author | Gnanapragasam, Vincent J. | |
dc.contributor.author | Barrett, Tristan | |
dc.contributor.editor | Baltzer, Pascal A. T. | |
dc.date.accessioned | 2022-09-12T09:15:03Z | |
dc.date.available | 2022-09-12T09:15:03Z | |
dc.date.issued | 2022-09-09 | |
dc.identifier.citation | Pantelidou , M , Caglic , I , George , A , Blyuss , O , Gnanapragasam , V J , Barrett , T & Baltzer , P A T (ed.) 2022 , ' Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes: A feasibility study ' , PLoS ONE , vol. 17 , no. 9 , e0274014 . https://doi.org/10.1371/journal.pone.0274014 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | Jisc: 593832 | |
dc.identifier.other | publisher-id: pone-d-22-06966 | |
dc.identifier.other | ORCID: /0000-0002-0194-6389/work/119159367 | |
dc.identifier.uri | http://hdl.handle.net/2299/25758 | |
dc.description | © 2022 Pantelidou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, https://creativecommons.org/licenses/by/4.0/ | |
dc.description.abstract | Purpose: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. Methods: Single-centre prospective study of patients undergoing MRI for suspected prostate cancer (PCa). Four combinations of US-volumes were calculated using transperineal (TP) and transabdominal (TA) views, with triplanar measurements to calculate volume and US-PSAD. Intra-class correlation coefficient (ICC) was used to compare US and MRI volumes. Categorical comparison of MRI-PSAD and US-PSAD was performed at PSAD cut-offs 0.20 ng/mL2 to assess agreement with MRI-PSAD risk-stratification decisions. Results: 64 men were investigated, mean age 69 years and PSA 7.0 ng/mL. 36/64 had biopsy-confirmed prostate cancer (18 Gleason 3+3, 18 Gleason ≥3+4). Mean MRI-derived gland volume was 60 mL, compared to 56 mL for TA-US, and 65 mL TP-US. ICC demonstrated good agreement for all US volumes with MRI, with highest agreement for transabdominal US, followed by combined TA/TP volumes. Risk-stratification decisions to biopsy showed concordant agreement between triplanar MRI-PSAD and ultrasound-PSAD in 86–91% and 92–95% at PSAD thresholds of >0.15 ng/mL2 and >0.12 ng/mL2, respectively. Decision to biopsy at threshold >0.12 ng/mL2, demonstrated sensitivity ranges of 81–100%, specificity 85–100%, PPV 86–100% and NPV 83–100%. Transabdominal US provided optimal sensitivity of 100% for this clinical decision, with specificity 85%, and transperineal US provided optimal specificity of 100%, with sensitivity 87%. Conclusion: Transperineal-US and combined TA-TP US-derived PSA density values compare well with standard MRI-derived values and could be used to provide accurate PSAD at presentation and inform the need for further investigations. | en |
dc.format.extent | 13 | |
dc.format.extent | 2127517 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS ONE | |
dc.subject | Research Article | |
dc.subject | Medicine and health sciences | |
dc.subject | Research and analysis methods | |
dc.subject | Biology and life sciences | |
dc.title | Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes: A feasibility study | en |
dc.contributor.institution | School of Physics, Engineering & Computer Science | |
dc.contributor.institution | Department of Physics, Astronomy and Mathematics | |
dc.contributor.institution | School of Computer Science | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1371/journal.pone.0274014 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |