| dc.contributor.author | Gill, C.H. | |
| dc.contributor.author | Bates, S.A. | |
| dc.contributor.author | Owen, D. | |
| dc.contributor.author | Larkman, P. | |
| dc.contributor.author | Cairns, W. | |
| dc.contributor.author | Yusuf, S. | |
| dc.contributor.author | Murdock, P. | |
| dc.contributor.author | Strijbos, P. | |
| dc.contributor.author | Powell, A. | |
| dc.contributor.author | Benham, C.D. | |
| dc.contributor.author | Davies, C.H. | |
| dc.date.accessioned | 2009-06-08T10:44:14Z | |
| dc.date.available | 2009-06-08T10:44:14Z | |
| dc.date.issued | 2004 | |
| dc.identifier.citation | Gill , C H , Bates , S A , Owen , D , Larkman , P , Cairns , W , Yusuf , S , Murdock , P , Strijbos , P , Powell , A , Benham , C D & Davies , C H 2004 , ' Characterization of the human HCN1 subunit and its inhibition by capsazepine ' , British Journal of Pharmacology , vol. 143 , no. 3 , pp. 411-421 . https://doi.org/10.1038/sj.bjp.0705945 | |
| dc.identifier.issn | 0007-1188 | |
| dc.identifier.other | dspace: 2299/3511 | |
| dc.identifier.uri | http://hdl.handle.net/2299/3511 | |
| dc.description | Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0705945 [Full text of this article is not available in the UHRA] | |
| dc.description.abstract | The human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. Activation of this recombinant channel, by membrane hyperpolarization, generated a slowly activating, noninactivating inward current. The pharmacological properties of hHCN1-mediated currents resembled those of native hyperpolarization-activated currents (Ih), that is, blockade by Cs+ (99% at 5 mM), ZD 7288 (98% at 100 μM) and zatebradine (92% at 10 μM). Inhibition of the hHCN1-mediated current by ZD 7288 was apparently independent of prior channel activation (i.e. non-use-dependent), whereas that induced by zatebradine was use-dependent. | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | British Journal of Pharmacology | |
| dc.title | Characterization of the human HCN1 subunit and its inhibition by capsazepine | en |
| dc.contributor.institution | Department of Human and Environmental Sciences | |
| dc.contributor.institution | TRP Ion channels | |
| dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
| dc.contributor.institution | Basic and Clinical Science Unit | |
| dc.contributor.institution | Centre for Health Services and Clinical Research | |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
| dc.description.status | Peer reviewed | |
| rioxxterms.versionofrecord | 10.1038/sj.bjp.0705945 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
