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dc.contributor.authorGill, C.H.
dc.contributor.authorBates, S.A.
dc.contributor.authorOwen, D.
dc.contributor.authorLarkman, P.
dc.contributor.authorCairns, W.
dc.contributor.authorYusuf, S.
dc.contributor.authorMurdock, P.
dc.contributor.authorStrijbos, P.
dc.contributor.authorPowell, A.
dc.contributor.authorBenham, C.D.
dc.contributor.authorDavies, C.H.
dc.date.accessioned2009-06-08T10:44:14Z
dc.date.available2009-06-08T10:44:14Z
dc.date.issued2004
dc.identifier.citationGill , C H , Bates , S A , Owen , D , Larkman , P , Cairns , W , Yusuf , S , Murdock , P , Strijbos , P , Powell , A , Benham , C D & Davies , C H 2004 , ' Characterization of the human HCN1 subunit and its inhibition by capsazepine ' , British Journal of Pharmacology , vol. 143 , no. 3 , pp. 411-421 . https://doi.org/10.1038/sj.bjp.0705945
dc.identifier.issn0007-1188
dc.identifier.otherPURE: 123295
dc.identifier.otherPURE UUID: af48e5b4-f3c0-4263-93d2-8627eda30146
dc.identifier.otherdspace: 2299/3511
dc.identifier.otherScopus: 7044221810
dc.identifier.urihttp://hdl.handle.net/2299/3511
dc.descriptionOriginal article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0705945 [Full text of this article is not available in the UHRA]
dc.description.abstractThe human hyperpolarization-activated cyclic nucleotide-gated 1 (hHCN1) subunit was heterologously expressed in mammalian cell lines (CV-1 and CHO) and its properties investigated using whole-cell patch-clamp recordings. Activation of this recombinant channel, by membrane hyperpolarization, generated a slowly activating, noninactivating inward current. The pharmacological properties of hHCN1-mediated currents resembled those of native hyperpolarization-activated currents (Ih), that is, blockade by Cs+ (99% at 5 mM), ZD 7288 (98% at 100 μM) and zatebradine (92% at 10 μM). Inhibition of the hHCN1-mediated current by ZD 7288 was apparently independent of prior channel activation (i.e. non-use-dependent), whereas that induced by zatebradine was use-dependent.en
dc.language.isoeng
dc.relation.ispartofBritish Journal of Pharmacology
dc.titleCharacterization of the human HCN1 subunit and its inhibition by capsazepineen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dcterms.dateAccepted2004
rioxxterms.versionofrecordhttps://doi.org/10.1038/sj.bjp.0705945
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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