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        The role of vehicle-nanoparticle interactions in topical drug delivery

        Author
        Moddaresi, Mojgan
        Brown, Marc
        Zhao, Yanjun
        Tamburic, Slobodanka
        Jones, Stuart A.
        Attention
        2299/5045
        Abstract
        Loading 'difficult to deliver' therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid preparations adds an extra dimension to the already complex process of topical drug delivery. The aim of this work was to understand how the mobility of nanoparticles influenced the delivery of a model drug when the carriers were suspended in a hyaluronic acid (HA) vehicle. Tocopheryl acetate (TA) was loaded into lipid nanoparticles (TA(LN)) that were <100 nm in size and physically stable for more than 28 days. The TA(LN) interacted with the HA polymeric chains to increase formulation macroviscosity. Nanoparticle tracking analysis confirmed that the gel hindered the TA(LN) mobility. However, deliberate manipulation of the particle mobility in the gel by varying the concentration of HA had little effect on TA delivery. Only ca. 10 mu g/cm(2) of administered TA was delivered into porcine skin regardless of the vehicle characteristics and this suggested that drug release from the LN was the rate limiting step in the delivery process and not the nanoparticle-vehicle-skin interactions. (C) 2010 Elsevier BM. All rights reserved.
        Publication date
        2010-11-15
        Published in
        International Journal of Pharmaceutics
        Published version
        https://doi.org/10.1016/j.ijpharm.2010.08.012
        Other links
        http://hdl.handle.net/2299/5045
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