Show simple item record

dc.contributor.authorModdaresi, Mojgan
dc.contributor.authorBrown, Marc
dc.contributor.authorZhao, Yanjun
dc.contributor.authorTamburic, Slobodanka
dc.contributor.authorJones, Stuart A.
dc.date.accessioned2010-11-30T15:48:37Z
dc.date.available2010-11-30T15:48:37Z
dc.date.issued2010-11-15
dc.identifier.citationModdaresi , M , Brown , M , Zhao , Y , Tamburic , S & Jones , S A 2010 , ' The role of vehicle-nanoparticle interactions in topical drug delivery ' International Journal of Pharmaceutics , vol. 400 , no. 1-2 , pp. 176-182 . https://doi.org/10.1016/j.ijpharm.2010.08.012
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 183209
dc.identifier.otherPURE UUID: 74b76dc5-ab01-4835-9d9a-8f295dd14b2c
dc.identifier.otherdspace: 2299/5045
dc.identifier.otherScopus: 77957670755
dc.identifier.otherWOS: 000283829900023
dc.identifier.urihttp://hdl.handle.net/2299/5045
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/03785173 Copyright Elsevier B.V. [Full text of this article is not available in the UHRA]
dc.description.abstractLoading 'difficult to deliver' therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid preparations adds an extra dimension to the already complex process of topical drug delivery. The aim of this work was to understand how the mobility of nanoparticles influenced the delivery of a model drug when the carriers were suspended in a hyaluronic acid (HA) vehicle. Tocopheryl acetate (TA) was loaded into lipid nanoparticles (TA(LN)) that were <100 nm in size and physically stable for more than 28 days. The TA(LN) interacted with the HA polymeric chains to increase formulation macroviscosity. Nanoparticle tracking analysis confirmed that the gel hindered the TA(LN) mobility. However, deliberate manipulation of the particle mobility in the gel by varying the concentration of HA had little effect on TA delivery. Only ca. 10 mu g/cm(2) of administered TA was delivered into porcine skin regardless of the vehicle characteristics and this suggested that drug release from the LN was the rate limiting step in the delivery process and not the nanoparticle-vehicle-skin interactions. (C) 2010 Elsevier BM. All rights reserved.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectLipid nanoparticles
dc.subjectRheology
dc.subjectPermeation
dc.subjectTopical formulation
dc.subjectNanoparticle tracking
dc.subjectSOLID LIPID NANOPARTICLES
dc.subjectPHASE INVERSION
dc.subjectHYALURONIC-ACID
dc.subjectIN-VITRO
dc.subjectRELEASE
dc.subjectCARRIERS
dc.subjectSKIN
dc.subjectVISCOELASTICITY
dc.subjectNANOCARRIERS
dc.subjectFORMULATIONS
dc.titleThe role of vehicle-nanoparticle interactions in topical drug deliveryen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77957670755&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2010.08.012
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record