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Browsing University of Hertfordshire by Author "Schilstra, M."
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Immunocytochemical localization of the elongation factor Tu in E. coli cells
Schilstra, M.; Slot, J.W.; Van der Meide, P.H.; Posthuma, G.; Cremers, A.F.M.; Bosch, L. (1984)The localization of the elongation factor Tu (EF-Tu) in ultrathin cryosections of E. coli cells was determined with the electron microscope using a highly specific immunological labellin technique. EF-Tu is distributed ... -
Kinetic analysis of the induction period in lipoxygenase catalysis
Schilstra, M.; Veldink, G.A.; Vliegenthart, J.F.G. (1993)The dioxygenation of 50 pM linoleate at 0.1 pM (13s)-hydroperoxylinoleate, 240 pM 02, pH 10, and 25 O C , catalyzed by varying amounts of soybean lipoxygenase-1, was studied with rapid kinetic techniques. The aim was to ... -
A knowledge-based diagnostic clinical decision support system for musculoskeletal disorders of the shoulder for use in a primary care setting
Farmer, Nicholas; Schilstra, M. (2012)Background Twenty percent of cases seen by primary care clinicians (general practitioners; GPs) are musculoskeletal in nature, and approximately one-quarter of these are shoulder complaints. GPs are increasingly overloaded ... -
A Lateral Cap model of microtubule dynamic instability
Bayley, P.M.; Schilstra, M.; Martin, S.R. (1989)The co-existence and interconversion of growing and shrinking microtubules have been termed ‘dynamic instability’, and have been directly observed to occur under a variety of conditions in vitro and in vivo. Previous ... -
Low-dose electron image reconstruction of negatively stained contractile phage sheath from Bacillus subtilis (PBS-Z)
Cremers, A.F.M.; Fischer, J.C.; Schilstra, M.; Mellema, J.E. (1979)The structure of the contractile sheath of the defective phage from B. subtilis (PBS-Z) has been investigated by low-dose electron microscopy and image reconstruction. The extended and contracted sheath particles were ... -
Mechanism of Lipoxygenase Inactivation by the Linoleic Acid Analogue Octadeca-9,12-diynoic Acid
Schilstra, M.; Nieuwenhuizen, W.F.; Veldink, G.A.; Vliegenthart, J.F.G. (1996)During the irreversible inactivation of soybean Fe(III)-lipoxygenase [Fe(III)-LOX] by octadeca-9,12-diynoic acid (ODYA), significant quantities of 11-oxooctadeca-9,12-diynoic acid (11-oxo-ODYA) are formed [Nieuwenhuizen, ... -
Methods for Simulating the Dynamics of Complex Biological Processes
Schilstra, M.; Martin, S.R.; Keating, S. (2008)In this chapter, we provide the basic information required to understand the central concepts in the modeling and simulation of complex biochemical processes. We underline the fact that most biochemical processes involve ... -
Microtubule dynamic instability: numerical simulation of microtubule transition properties using a Lateral Cap model
Bayley, P.M.; Schilstra, M.; Martin, S.R. (1990)We present a numerical formulation for the dynamic instability of microtubules involving the stabilisation of growing microtubules by a single layer of tubulin-GTP, with GTP hydrolysis effectively coupled to tubulin-GTP ... -
Microtubule dynamics: experimental evidence and numerical modelling
Bayley, P.M.; Gal, V.; Karecla, P.; Martin, S.R.; Schilstra, M.; Engelborghs, Y. (1988) -
Modulation of Quantum Yield of Primary Radical Pair Formation in Photosystem II by Site-Directed Mutagenesis Affecting Radical Cations and Anions
Merry, S.A.P.; Nixon, P.L.; Barter, L.; Schilstra, M.; Porter, G.; Barber, J.; Durrant, J.R.; Klug, D.R. (1998)Pigment−protein interactions play a significant role in determining the properties of photosynthetic complexes. Site-directed mutants of Synechocystis PCC 6803 have been prepared which modify the redox potential of the ... -
The NetBuilder project: development of a tool for constructing, simulating, evolving, and analysing complex regulatory networks
Wegner, K.; Knabe, J.; Robinson, M.; Egri-Nagy, A.; Schilstra, M. (2007) -
New Computational Approaches for Analysis of cis-Regulatory Networks
Brown, C.T.; Rust, A.G.; Clarke, P.J.C.; Pan, Z.; Schilstra, M.; De Buysscher, T.; Griffin, G.; Wold, B.J.; Cameron, R.A.; Davidson, E.H.; Bolouri, H. (2002) -
On the relationship between nucleotide hydrolysis and microtubule assembly : Studies with a GTP-regenerating system
Schilstra, M.; Martin, S.R.; Bayley, P.M. (1987)The assembly of pure tubulin dimer has been studied in two buffer systems (containing low and high glycerol/Mg), using a regeneration system protocol to assess the amount of GDP-tubulin in the assembling polymer. For both ... -
Opposite-end behaviour of dynamic microtubules
Martin, S.R.; Schilstra, M.; Bayley, P.M. (1991)Microtubules are dynamic polar structures with different kinetic properties at the two ends. The inherent asymmetry of the microtubule lattice determines that the relationship between the addition reaction of tubulin-GTP ... -
Proton/Hydrogen Transfer Affects the S-State-Dependent Microsecond Phases of P680+ Reduction during Water Splitting
Schilstra, M.; Rappaport, F.; Nugent, J.; Barnett, C.J.; Barber, J.; Klug, D.R. (1998)To investigate a possible coupling between P680+ reduction and hydrogen transfer, we studied the effects of H2O/D2O exchange on the P680+ reduction kinetics in the nano- and microsecond domains. We concentrated on studying ... -
A provisonal regulatory gene network for specification of endomesoderm in the sea urchin embryo
Davidson, E.H.; Rast, J.P.; Oliveri, P.; Ransick, A.; Calestani, C.; Yuh, C.H.; Minokawa, T.; Amore, G.; Hinman, V.; Arenas-Mena, C.; Otim, O.; Brown, C.T.; Livi, C.B.; Lee, P.Y.; Revilla, R.; Schilstra, M.; Clarke, P.J.C.; Rust, A.G.; Pan, Z.; Arnone, M.I.; Rowen, L.; Cameron, R.A.; McClay, D.R.; Hood, L.; Bolouri, H. (2002)We present the current form of a provisional DNA sequence-based regulatory gene network that explains in outline how endomesodermal specification in the sea urchin embryo is controlled. The model of the network is in a ... -
Rapid Kinetic Techniques
Eccleston, J.F.; Martin, S.R.; Schilstra, M. (2008) -
Regulation of gene regulation - smooth binding with dynamic affinity affects evolvability
Knabe, J.; Nehaniv, C.L.; Schilstra, M. (Institute of Electrical and Electronics Engineers (IEEE), 2008) -
Relationship between Excitation Energy Transfer, Trapping, and Antenna Size in Photosystem II
Barter, L.; Bianchietti, M.; Jeans, C.; Schilstra, M.; Hankamer, B.; Diner, B.A.; Barber, J.; Durrant, J.R.; Klug, D.R. (2001) -
Replacement of Tyrosine D with Phenylalanine Affects the Normal Proton Transfer Pathways for the Reduction of P680+ in Oxygen-Evolving Photosystem II Particles from Chlamydomonas
Jeans, C.; Schilstra, M.; Ray, N.; Husain, S.; Minagawa, J.; Nugent, J.; Klug, D.R. (2002)