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CCR2B receptor antagonists : Conversion of a weak HTS hit to a potent lead compound
Forbes, Ian T.; Cooper, David G.; Dodds, Emma K.; Hickey, Deirdre M. B.; Ife, Robert J.; Meeson, Malcolm; Stockley, Martin; Berkhout, Theo; Gohil, Jayneeta; Groot, Pieter H. E.; Moores, Kitty E. (2000-08-21)A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.